2,7-dimethyl-quinoxaline 1,4-dioxide | 23465-90-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2,7-dimethyl-quinoxaline 1,4-dioxide
• 英文别名: 3,6-Dimethyl-4-oxidoquinoxalin-1-ium 1-oxide
• CAS: 23465-90-9
• 化学式: C₁₀H₁₀N₂O₂
• 分子量: 190.202
• InChiKey: SOGFLVNHJCXNMH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  46.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  、 丙醛 在 吗啉 作用下， 生成 2,7-dimethyl-quinoxaline 1,4-dioxide
  参考文献：
  名称：

  Synthesis and Biological Evaluation of New Quinoxaline Derivatives as Antioxidant and Anti-Inflammatory Agents

  摘要：

  We report the synthesis, anti‐inflammatory, and antioxidant activities of novel quinoxaline and quinoxaline 1,4‐di‐N‐oxide derivatives. Microwave‐assisted methods have been used to optimize reaction times and to improve yields. The tested compounds presented important scavenging activities and promising in vitro inhibition of soybean lipoxygenase (LOX). Two of the best LOX inhibitors (compounds 7b and 8f) were evaluated as in vivo anti‐inflammatory agents using the carrageenin‐induced edema model. One of them (compound 7b) showed important in vivo anti‐inflammatory effect (41%) similar to that of indomethacin (47%) used as the reference drug.

  DOI：

  10.1111/j.1747-0285.2011.01076.x

文献信息

• US4317824A
  申请人：——

  公开号：US4317824A

  公开（公告）日：1982-03-02