2-(2,5-dihydroxyphenyl)-N-[(4-methoxyphenyl)methyl]acetamide | 1452176-76-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-(2,5-dihydroxyphenyl)-N-[(4-methoxyphenyl)methyl]acetamide
• CAS: 1452176-76-9
• 化学式: C₁₆H₁₇NO₄
• 分子量: 287.315
• InChiKey: AMTFADZVXUZHBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  78.8
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] NOVEL COMPOUNDS AND USES THEREOF<br/>[FR] NOUVEAUX COMPOSÉS ET UTILISATIONS DE CEUX-CI
  申请人：NANYANG POLYTECHNIC

  公开号：WO2013130013A1

  公开（公告）日：2013-09-06

  The invention relates to use of compounds represented by the general formula (I) and pharmaceutically acceptable salts thereof, wherein n is an integer from 2 to 5; p is an integer from 0 to 4; R1 is independently selected from the group consisting of a hydroxyl group, an alkoxy group, a thiol group, and a thioether group, wherein at least two of R1 are on the carbon-2 and carbon-5 positions of the phenyl group; R2 and R3 are independently a methylene group or a nucleophile; Z is an oxygen (O) atom or sulfur (S) atom; and T is hydrogen or an optionally substituted aliphatic group or optionally substituted aryl group; in the manufacture of a medicament for prevention and/or treatment and/or containment of a condition associated with a cell proliferative disorder.

  该发明涉及使用由一般式（I）表示的化合物及其在制备与细胞增殖紊乱相关的病症的预防和/或治疗和/或控制药物中的药用盐，其中n是从2到5的整数；p是从0到4的整数；R1是从羟基、烷氧基、硫醇基和硫醚基组成的群体中独立选择的，其中至少有两个R1位于苯基的碳-2和碳-5位置；R2和R3分别是亚甲基基团或亲核试剂；Z是氧（O）原子或硫（S）原子；T是氢或选择性取代的脂肪基团或选择性取代的芳基团。