| 1152321-59-9

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• CAS: 1152321-59-9
• 化学式: C₁₁₀H₁₂₁N₃₁O₄₆P₈
• 分子量: 2861.14
• InChiKey: ZLEVHGGUGUOIIV-AUONRYJGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.44
• 重原子数：
  195.0
• 可旋转键数：
  52.0
• 环数：
  27.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  1062.08
• 氢给体数：
  19.0
• 氢受体数：
  66.0

反应信息

• 作为产物：
  描述：

  、 1-芘甲胺 盐酸盐 在 4-二甲氨基吡啶 、 三苯基膦 作用下， 以 二甲基亚砜 为溶剂， 反应 2.25h， 以42%的产率得到
  参考文献：
  名称：

  Oligo(2′-O-methylribonucleotides) and their derivatives: III. 5′-Mono- and 5′-bispyrenyl derivatives of oligo(2′-O-methylribonucleotides) and their 3′-modified analogues: Synthesis and properties

  摘要：

  5 '-Pyrenylmethylphosphamide and 5 '-bispyrenylmethylphosphordiamide derivatives of oligo(2 '-O-methylribonucleotides) and their analogues with thymidine attached at their 3'-termini by a 3 '-3 '-phosphodiester internucleotide bond ("inverted" thymidine) were synthesized. The effect of the pyrene residue(s) on the thermal stability of duplexes of the modified oligonucleotides with RNA and DNA was studied. A possibility of detection of hybridization of 5 '-mono- and 5 '-bispyrenyl derivatives with RNA and DNA targets in solution was demonstrated according to the changes in fluorescence. 5 '-Pyrenylphosphamide derivatives of oligo(2 '-O-methylribonucleotides) and their inverted analogues were shown to be used as sensitive probes for the detection of single nucleotide polymorphisms in RNA and DNA by the method of thermal duplex denaturation with fluorescence change registration.

  DOI：

  10.1134/s1068162008050105