2-chloro-3-(2-methoxyphenyl)-5-methyl-5-(4-methylsulfonylphenyl)-7H-thieno[2,3-b]pyridine-4,6-dione | 1313504-01-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: 2-chloro-3-(2-methoxyphenyl)-5-methyl-5-(4-methylsulfonylphenyl)-7H-thieno[2,3-b]pyridine-4,6-dione
• CAS: 1313504-01-6
• 化学式: C₂₂H₁₈ClNO₅S₂
• 分子量: 475.974
• InChiKey: MYNJTERUBUKRFB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  126
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] THIENO [2,3-B] PYRIDINEDIONE ACTIVATORS OF AMPK AND THERAPEUTIC USES THEREOF<br/>[FR] ACTIVATEURS THIÉNO [2,3-B] PYRIDINEDIONE DE L'AMPK ET UTILISATIONS THÉRAPEUTIQUES DE CEUX-CI
  申请人：POXEL

  公开号：WO2011080277A1

  公开（公告）日：2011-07-07

  The invention relates to compounds that are direct activators of AMPK (AMP- activated protein kinase) and their use in the treatment of disorders regulated by activation of AMPK. For instance, compounds according to the invention are useful for the treatment of diabetes, metabolic syndrome, obesity, inflammation, cancer and cardiovascular diseases.

  这项发明涉及直接激活AMPK（AMP-激活蛋白激酶）的化合物及其在治疗受AMPK激活调节的疾病中的应用。例如，根据该发明的化合物可用于治疗糖尿病、代谢综合征、肥胖、炎症、癌症和心血管疾病。
• THIENO [2,3-B]PYRIDINEDIONE ACTIVATORS OF AMPK AND THERAPEUTIC USES THEREOF
  申请人：Poxel

  公开号：EP2519527A1

  公开（公告）日：2012-11-07
• THIENO[2,3-B]PYRIDINEDIONE ACTIVATORS OF AMPK AND THERAPEUTIC USES THEREOF
  申请人：Poxel

  公开号：EP2519527B1

  公开（公告）日：2013-12-18
• THIENO [2,3-B] PYRIDINEDIONE ACTIVATORS OF AMPK AND THERAPEUTIC USES THEREOF
  申请人：Cravo Daniel

  公开号：US20130053401A1

  公开（公告）日：2013-02-28

  The invention relates to compounds that are direct activators of AMPK (AMP-activated protein kinase) and their use in the treatment of disorders regulated by activation of AMPK. For instance, compounds according to the invention are useful for the treatment of diabetes, metabolic syndrome, obesity, inflammation, cancer and cardiovascular diseases.
• US9365584B2
  申请人：——

  公开号：US9365584B2

  公开（公告）日：2016-06-14