(3aR,7aS)-1,3,3a,4,7,7a-Hexahydro-inden-2-one oxime | 25886-64-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (3aR,7aS)-1,3,3a,4,7,7a-Hexahydro-inden-2-one oxime
• CAS: 25886-64-0
• 化学式: C₉H₁₃NO
• 分子量: 151.208
• InChiKey: MELGDDNFBQIRSF-TWEHFBLQSA-N

物化性质

• 沸点：
  273.8±29.0 °C(Predicted)
• 密度：
  1.23±0.1 g/cm3(Predicted)

文献信息

• Bicyclooctane derivatives and their production and use
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0092963A1

  公开（公告）日：1983-11-02

  A compound of the formula wherein X' is a free or an esterified carboxyl group, or a group of the formula: (Ra and Rb are each independently a hydrogen atom, a C1-C4 alkyl group, a C3-C7 cycloalkyl group, a benzyl group, a phenyl group, a phenyl group substituted with a halogen atom of a C,-C4 alkyl group, or, when taken together with the adjacent nitrogen atom to which they are attached, they represent a 5 to 7 membered saturated heterocyclic group), Y is a group of the formula: (R6 is a hydrogen atom or a C1-C4 alkyl group) or (R6 is as defined above), R' is a hydrogen atom, a hydroxyl group or a protected hydroxyl group, R2 is a hydrogen atom or R' and R2, when taken together, mean a single linkage to form a double bond between the carbon atoms which they are linked, R3 is a hydroxyl group or a protected hydroxyl group, R4 is a hydrogen atom or a C,-C4 alkyl group, R5 is a hydrogen atom, a C3 - C8 alkynyl group, a C3-C8 alkenyl group, a C1-C8 alkyl group, a C3-C7 cycloalkyl group, a hydroxy C1-C8 alkyl group or a group of the formula: -(CH2)m-B (m is 1 or 2 and B is C,-C4 alkoxy, a C3-C7 cycloalkyl, or a phenyl or phenoxy group optionally substituted with a halogen atom, a C1-C4 alkyl group, a trifluoromethyl group or a C1-C4 alkoxy group), n is 2 or 3; or a non-toxic pharmaceutically acceptable salt thereof has strong anti- cancer activity and is useful in treatment of a cancer.

  式中的化合物 其中 X'是游离的或酯化的羧基，或式中的基团： (Ra和Rb各自独立地为氢原子、C1-C4烷基、C3-C7环烷基、苄基、苯基、被C,-C4烷基的卤素原子取代的苯基，或当与相连的相邻氮原子合在一起时，它们代表5至7个成员的饱和杂环基团），Y为式中的基团： (R6 是氢原子或 C1-C4 烷基）或 (R6 如上定义），R'是氢原子、羟基或受保护的羟基，R2 是氢原子或 R'和 R2 合在一起时表示单链，在它们所连接的碳原子之间形成双键、R3 是羟基或受保护的羟基，R4 是氢原子或 C,-C4烷基，R5 是氢原子、C3-C8 炔基、C3-C8 烯基、C1-C8 烷基、C3-C7 环烷基、羟基 C1-C8 烷基或式中的基团：-(CH2)m-B（m 为 1 或 2，B 为 C、-C4 烷氧基、C3-C7 环烷基、或任选被卤素原子、C1-C4 烷基、三氟甲基或 C1-C4 烷氧基取代的苯基或苯氧基），n 为 2 或 3；或其无毒药学上可接受的盐，具有很强的抗癌活性，可用于治疗癌症。
• US4537989A
  申请人：——

  公开号：US4537989A

  公开（公告）日：1985-08-27