2-(benzylideneamino)-3-(indol-3-yl)propionatebis-(1,10-phenanthroline)cobalt(II) chloride | 1407181-91-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-(benzylideneamino)-3-(indol-3-yl)propionatebis-(1,10-phenanthroline)cobalt(II) chloride
• CAS: 1407181-91-2
• 化学式: C₄₂H₃₁CoN₆O₂*Cl
• 分子量: 746.193
• InChiKey: YMZFXJSNLFPCKG-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  1,10-菲罗啉 、 potassium 2-(benzylideneamino)-3-(indol-3-yl)propionate 、 cobalt(II) chloride 以 甲醇 、 乙醇 为溶剂， 反应 2.0h， 以71%的产率得到2-(benzylideneamino)-3-(indol-3-yl)propionatebis-(1,10-phenanthroline)cobalt(II) chloride
  参考文献：
  名称：

  Probing the DNA-binding behavior of tryptophan incorporating mixed-ligand complexes

  摘要：

  Mixed-ligand Cu(II), Ni(II), Co(II), and Zn(II) complexes using a tryptophan-derived Schiff base (obtained by the condensation of tryptophan and benzaldehyde) as the primary ligand and 1,10-phenanthroline as the co-ligand were synthesized and characterized analytically and spectroscopically by performing elemental analyses, magnetic susceptibility and molar conductance measurements, UV-Vis, IR, NMR, and FAB-MS. The binding properties of metal complexes with DNA were investigated by electronic absorption spectroscopy, cyclic voltammetry, and by performing viscosity measurements, and the results showed that these complexes have the ability to interact with DNA via an intercalative mode. The DNA cleavage efficiencies of these complexes with pUC19 DNA were investigated by gel electrophoresis. The complexes were found to promote the cleavage of pUC19 DNA from the supercoiled form I to the open circular form II and the linear form III in the presence of ascorbic acid. Finally, the in vitro antibacterial activities of the Schiff base and its mixed-ligand metal complexes were screened against the bacteria Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, Escherichia coli, and Salmonella typhi. The antibacterial screening data revealed that the complexes show growth inhibitory activity against bacteria.

  DOI：

  10.1007/s00706-012-0718-4