N-(1-ethyl-8-fluoro-3-methyl-imidazo[1,5-a]quinoxalin-4-yl)-methanesulfonamide | 1159694-99-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-(1-ethyl-8-fluoro-3-methyl-imidazo[1,5-a]quinoxalin-4-yl)-methanesulfonamide
• 英文别名: N-(1-ethyl-8-fluoro-3-methylimidazo[1,5-a]quinoxalin-4-yl)methanesulfonamide
• CAS: 1159694-99-1
• 化学式: C₁₄H₁₅FN₄O₂S
• 分子量: 322.363
• InChiKey: GOJDDUORCWBCFB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  84.7
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Aryl and heteroaryl fused imidazo [1,5-a] pyrazines as inhibitors of phosphodiesterase 10
  申请人：Hofgen Norbert

  公开号：US20090143391A1

  公开（公告）日：2009-06-04

  The invention relates to imidazo[1,5-a]pyrazine derivatives, to processes for preparing them, to pharmaceutical preparations which comprise these compounds and to the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 10 (PDE10), as active compounds for treating central nervous system diseases of mammals, including humans.

  该发明涉及咪唑并[1,5-a]吡嗪衍生物，涉及制备它们的方法，包括这些化合物的药物制剂以及这些化合物的药用，这些化合物是磷酸二酯酶10（PDE10）的抑制剂，作为治疗哺乳动物中枢神经系统疾病的活性化合物，包括人类。
• ARYL AND HETEROARYL FUSED IMIDAZO (1,5-A) PYRAZINES AS INHIBITORS OF PHOSPHODIESTERASE 10
  申请人：Elbion Gmbh

  公开号：EP2227472A1

  公开（公告）日：2010-09-15
• [EN] ARYL AND HETEROARYL FUSED IMIDAZO (1,5-A) PYRAZINES AS INHIBITORS OF PHOSPHODIESTERASE 10<br/>[FR] IMIDAZO[1,5-A]PYRAZINES FUSIONNÉES À ARYLE ET HÉTÉROARYLE COMME INHIBITEUR DE LA PHOSPHODIESTÉRASE 10
  申请人：ELBION GMBH

  公开号：WO2009068320A1

  公开（公告）日：2009-06-04

  The invention relates to imidazo[1,5-a]pyrazine derivatives, to processes for preparing them, to pharmaceutical preparations which comprise these compounds and to the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 10 (PDE10), as active compounds for treating central nervous system diseases of mammals, including humans.