3,6-dichloro-naphthalene-2-sulfonyl chloride | 123091-54-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3,6-dichloro-naphthalene-2-sulfonyl chloride
• 英文别名: 3,6-Dichlor-naphthalin-2-sulfonylchlorid；3,6-dichloronaphthalen-2-ylsulfonyl chloride；3,6-dichloronaphthalene-2-sulfonyl chloride
• CAS: 123091-54-3
• 化学式: C₁₀H₅Cl₃O₂S
• 分子量: 295.573
• InChiKey: UJICQTKAOGLMHQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  聚甘氨酸 、 3,6-dichloro-naphthalene-2-sulfonyl chloride 生成 N-(3,6-dichloronaphthalen-2-ylsulfonyl)glycine
  参考文献：
  名称：

  MOTIDA, SUGURU;KATO, KADZUO;KATO, KATSUAKI;MIVA, ITITOMO;OKUDA, DZYUN

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 五氯化磷 作用下， 生成 3,6-dichloro-naphthalene-2-sulfonyl chloride
  参考文献：
  名称：

  43.衍生自四氯化二氯萘和三氯萘磺酸的四氯萘

  摘要：

  DOI：

  10.1039/jr9410000243

文献信息

• Hydantoin derivatives
  申请人：Mochida Pharmaceutical Co., Ltd.

  公开号：US05004751A1

  公开（公告）日：1991-04-02

  The present invention relates to novel hydantoin derivatives, processes for producing said hydantoin derivatives, pharmaceutical compositions containing at least one of said hydantoin derivatives as aldose reductase inhibitors and novel intermediate compounds in the synthesis of said hydantoin derivatives. The present invention is based on the selection of a hydantoin which is bonded by a sulfonyl group to various substituents at the 1-position of the hydantoin skeleton. The compounds of the present invention have a strong inhibitory activity against aldose reductase. These compounds are extremely useful for the treatment and/or prevention of various forms of diabetic complications based on the accumulation of polyol metabolites.

  本发明涉及新型咪唑烷酮衍生物，生产所述咪唑烷酮衍生物的方法，含有至少一种所述咪唑烷酮衍生物作为醛糖还原酶抑制剂的药物组合物，以及在合成所述咪唑烷酮衍生物中的新型中间化合物。本发明基于选择一种咪唑烷酮，该咪唑烷酮通过磺酰基与咪唑烷酮骨架的1位上的各种取代基结合。本发明的化合物对醛糖还原酶具有强烈的抑制活性。这些化合物对于治疗和/或预防基于多元醇代谢产物积累的各种糖尿病并发症非常有用。
• Hydantoin derivatives as aldose reductase inhibitors
  申请人：Mochida Pharmaceutical Co., Ltd.

  公开号：US04914099A1

  公开（公告）日：1990-04-03

  The present invention relates to novel hydantoin derivatives, processes for producing said hydantoin derivatives, pharmaceutical compositions containing at least one of said hydantoin derivatives as aldose reductase inhibitors and novel intermediate compounds in the synthesis of said hydantoin derivatives. The present invention is based on the selection of a hydantoin which is bonded by a sulfonyl group to various substituents at the 1-position of the hydantoin skeleton.

  本发明涉及新的噻唑二酮衍生物，制备该噻唑二酮衍生物的方法，包含至少一种该噻唑二酮衍生物作为醛糖还原酶抑制剂的制药组合物以及合成该噻唑二酮衍生物的新中间化合物。本发明基于选择将噻唑二酮通过磺酰基与噻唑二酮骨架的1位上的各种取代基结合。
• Cercis plant named ‘NC2017-6’
  申请人：North Carolina State University

  公开号：USPP035279P3

  公开（公告）日：2023-07-25

  A new and distinct variety of Cercis plant, referred to by its cultivar name ‘NC2017-6’, is disclosed. The new cultivar originated in a controlled breeding program. Plants of the new variety produce small and purple-colored foliage. The new variety is moderately vigorous. Plants of the new variety exhibit a highly branched, and compact growth habit.

  一种新的、独特的紫荆植物品种，以其栽培品种名称“NC2017-6”命名，已经被揭示。这个新的品种起源于一个受控的育种计划。这个新品种的植物产生小而紫色的叶子。这个新品种是适度有活力的。这个新品种的植物表现出高度分枝和紧凑的生长习性。
• Hydantoin derivatives, process for their preparation and pharmaceutical compositions containing the same as well as their use
  申请人：MOCHIDA PHARMACEUTICAL CO., LTD.

  公开号：EP0305947A1

  公开（公告）日：1989-03-08

  The present invention relates to novel hydantoin derivatives, processes for producing said hydantoin 'derivatives, pharmaceutical compositions containing at least one of said hydantoin derivatives as aldose reductase inhibitors and novel intermediate compounds in the synthesis of said hydantoin derivatives. The present invention is based on the selection of a hydantoin which is bonded by a sulfonyl group to various substituents at the 1-position of the hydantoin skeleton. The compounds of the present invention have a strong inhibitory activity against aldose reductase. These compounds are extremely useful for the treatment and/or prevention of various forms of diabetic complications based on the accumulation of polyol metabolites.

  本发明涉及新型海因衍生物、生产所述海因'衍生物的工艺、含有至少一种所述海因衍生物作为醛糖还原酶抑制剂的药物组合物以及合成所述海因衍生物的新型中间化合物。 本发明的基础是选择一种通过磺酰基键合在海因骨架 1 位上的各种取代基上的海因。 本发明的化合物对醛糖还原酶具有很强的抑制活性。这些化合物对于治疗和/或预防基于多元醇代谢产物积累的各种糖尿病并发症极为有用。
• MOTIDA, SUGURU;KATO, KADZUO;KATO, KATSUAKI;MIVA, ITITOMO;OKUDA, DZYUN
  作者：MOTIDA, SUGURU、KATO, KADZUO、KATO, KATSUAKI、MIVA, ITITOMO、OKUDA, DZYUN

  DOI：——

  日期：——