1-chlorobenzo[f]quinazoline | 1272661-22-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 1-chlorobenzo[f]quinazoline
• CAS: 1272661-22-9
• 化学式: C₁₂H₇ClN₂
• 分子量: 214.654
• InChiKey: QIHSIJWAFDWAIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-chlorobenzo[f]quinazoline 在 N,N-二甲基乙二胺 、 异丙醇 作用下， 反应 0.25h， 生成 benzo[f]quinazolin-1(2H)-one
  参考文献：
  名称：

  Benzoquinazoline derivatives as new agents affecting DNA processing

  摘要：

  A new series of benzo[h]quinazoline and benzo[f]quinazoline derivatives was prepared and studied for the biological activity. The compounds carrying a dimethylaminoethyl side chain (6c, 8c and 12) inhibit cell growth. The ability to form a molecular complex with DNA and to interfere with topoll and topol relaxation activity was evidenced for the most active 6c and 8c, along with the capacity to induce apoptosis on HeLa cells. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.12.037
• 作为产物：
  描述：

  benzo[f]quinazolin-1(2H)-one 在 四氯化碳 、 三苯基膦 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以48%的产率得到1-chlorobenzo[f]quinazoline
  参考文献：
  名称：

  Benzoquinazoline derivatives as new agents affecting DNA processing

  摘要：

  A new series of benzo[h]quinazoline and benzo[f]quinazoline derivatives was prepared and studied for the biological activity. The compounds carrying a dimethylaminoethyl side chain (6c, 8c and 12) inhibit cell growth. The ability to form a molecular complex with DNA and to interfere with topoll and topol relaxation activity was evidenced for the most active 6c and 8c, along with the capacity to induce apoptosis on HeLa cells. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.12.037

文献信息

• Inhibitors of KRAS G12C mutant proteins
  申请人：Araxes Pharma LLC

  公开号：US10280172B2

  公开（公告）日：2019-05-07

  Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): or a pharmaceutically acceptable salt, tautomer, stereoisomer or prodrug thereof, wherein B, W, X, Y, R1, R2a, R2b, R3a, R3b, R4a, R4b, G1, G2, m1, m2, L1, L2 and E are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, are also provided.

  本研究提供了具有抑制 G12C 突变 KRAS 蛋白活性的化合物。这些化合物具有以下结构 (I)： 或其药学上可接受的盐、同系物、立体异构体或原药，其中 B、W、X、Y、R1、R2a、R2b、R3a、R3b、R4a、R4b、G1、G2、m1、m2、L1、L2 和 E 如本文所定义。还提供了与制备和使用此类化合物相关的方法、包含此类化合物的药物组合物以及调节 G12C 突变 KRAS 蛋白活性以治疗疾病（如癌症）的方法。
• [EN] METAL COMPLEX AND APPLICATION THEREOF<br/>[FR] COMPLEXE MÉTALLIQUE ET SON UTILISATION<br/>[ZH] 一种金属配合物及其应用
  申请人：GUANGDONG AGLAIA OPTOELECTRONIC MAT CO LTD

  公开号：WO2021120741A1

  公开（公告）日：2021-06-24

  一种金属配合物，具有化学式(I)结构，该化合物应用于有机电致发光器件中，发射深红光或者近红外光，表现出较低的驱动电压，较高的发光效率，且使用寿命也有很大程度的提升，有潜力应用于有机电致发光器件领域。还提供了一种有机电致光电器件，包括阴极、阳极和有机层，所述有机层为空穴注入层、空穴传输层、发光层、空穴阻挡层、电子传输层、电子注入层中的一层或多层，有机层中至少有一层含有结构式(I)中的化合物。(I)
• INHIBITORS OF KRAS G12C MUTANT PROTEINS
  申请人：Araxes Pharma LLC

  公开号：US20180155348A1

  公开（公告）日：2018-06-07

  Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): or a pharmaceutically acceptable salt, tautomer, stereoisomer or prodrug thereof, wherein B, W, X, Y, R 1 , R 2a , R 2b , R 3a , R 3b , R 4a , R 4b , G 1 , G 2 , m 1 , m 2 , L 1 , L 2 and E are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, are also provided.
• METAL COMPLEX AND APPLICATION THEREOF
  申请人：GUANGDONG AGLAIA OPTOELECTRONIC MATERIALS CO., LTD

  公开号：US20220411452A1

  公开（公告）日：2022-12-29

  The present invention relates to a metal complex having a structure of chemical formula (I). The metal complex is applied to an organic light-emitting device which emits deep red or near-infrared light, and shows a lower driving voltage and higher luminous efficiency, and has greatly prolonged service life. Therefore, the metal complex has the potential of being applied in the field of organic light-emitting devices. Also provided is an organic light-emitting device, including a cathode, an anode, and an organic layer. The organic layer is one or more of a hole injection layer, a hole transport layer, a light-emitting layer, a hole blocking layer, an electron transport layer, and an electron injection layer; and at least one layer in the organic layer contains the compound of structural formula (I).