1-Piperidino-1-phenyl-pentan | 93145-01-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-Piperidino-1-phenyl-pentan
• 英文别名: 1-(1-phenyl-pentyl)-piperidine；1-(1-Phenylpentyl)piperidine
• CAS: 93145-01-8
• 化学式: C₁₆H₂₅N
• 分子量: 231.381
• InChiKey: LRIGRSPMFXXINE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-(phenylselenocarbonyl) piperidine 、 正丁基锂 生成 1-Piperidino-1-phenyl-pentan
  参考文献：
  名称：

  SEKIGUCHI, MASAHITO;OGAWA, AKIYA;FUJIWARA, SHIN-ICHI;RYU, ILHYONG;KAMBE, +, CHEM. LETT.,(1990) N1, C. 2053-2056

  摘要：

  DOI：

文献信息

• A Novel Deselenation in the Reaction of Selenoamides with Organolithium Reagents
  作者：Masahito Sekiguchi、Akiya Ogawa、Shin-Ichi Fujiwara、Ilhyong Ryu、Nobuaki Kambe、Noboru Sonoda

  DOI：10.1246/cl.1990.2053

  日期：1990.11

  The reaction of selenoamides with organolithium reagents proceeds in a carbophilic manner, and more interestingly, the presence of excess lithium reagents causes a novel deselenation reaction from the carbophilic adducts.

  硒酰胺与有机锂试剂的反应以亲碳化方式进行，更有趣的是，过量锂试剂的存在会导致碳亲化加合物发生新的脱硒反应。
• Generation and Reactivity of α-Amino-Substituted Arylmethyllithium Organometallics
  作者：Ugo Azzena、Luciano Pilo、Elisabetta Piras

  DOI：10.1016/s0040-4020(00)00303-3

  日期：2000.6

  Reductive cleavage of open chain and cyclic α-N,N-dialkylamino-substituted benzyl alkyl ethers 1a–f with a dispersion of Li metal and a catalytic amount of naphthalene in THF, allowed easy access to a wide array of α-N,N-dialkylamino-substituted benzyllithium derivatives. Reaction of these organometallics with various electrophiles afforded the expected products in satisfactory yields.

  开链和环状α - N，N-二烷基氨基取代的苄基烷基醚1a - f的还原裂解，分散有Li金属和催化量的萘在THF中，可以轻松获得各种α- N，N -二烷基氨基取代的苄基锂衍生物。这些有机金属与各种亲电试剂的反应以令人满意的产率提供了预期的产物。
• Mixed Aliphatic Organozinc Reagents as Nonstabilized C_sp³-Nucleophiles in the Multicomponent Mannich Reaction
  作者：Marine Pinaud、Erwan Le Gall、Marc Presset

  DOI：10.1021/acs.joc.1c02996

  日期：2022.4.1

  use of mixed aliphatic organozinc reagents in the multicomponent Mannich reaction is described. A large variety of primary, secondary, and tertiary organozinc reagents, secondary amines and aromatic or aliphatic aldehydes could be used for the straightforward preparation of densely substituted amines. The three-component reaction could additionally be performed starting from alkyl halides under reductive

  描述了在多组分曼尼希反应中使用混合脂肪族有机锌试剂。大量的伯、仲和叔有机锌试剂、仲胺和芳族或脂族醛可用于直接制备密集取代的胺。三组分反应还可以在还原（巴比尔型）条件下从卤代烷开始进行。