(+/-)-3-(6-iodo-pyridazin-3-yloxy)-1-aza-bicyclo[2.2.2]octane | 883239-24-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 奎宁环
• 英文名称: (+/-)-3-(6-iodo-pyridazin-3-yloxy)-1-aza-bicyclo[2.2.2]octane
• 英文别名: 3-(6-Iodopyridazin-3-yl)oxy-1-azabicyclo[2.2.2]octane
• CAS: 883239-24-5
• 化学式: C₁₁H₁₄IN₃O
• 分子量: 331.156
• InChiKey: HPCRQUVIHCWSAI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  38.2
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] NOVEL AZABICYCLIC ARYL DERIVATIVES AND THEIR MEDICAL USE<br/>[FR] NOUVEAUX DERIVES ARYLES AZABICYCLIQUES ET LEUR UTILISATION MEDICALE
  申请人：NEUROSEARCH AS

  公开号：WO2006040352A1

  公开（公告）日：2006-04-20

  This invention relates to novel azabicyclic aryl derivatives of formula (I), which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  该发明涉及一种新型的式(I)的氮杂双环芳基衍生物，发现它们是乙酰胆碱受体的胆碱能配体，同时也是单胺受体和转运体的调节剂。由于它们的药理特性，本发明的化合物可能对治疗与中枢神经系统（CNS）的胆碱能系统、外周神经系统（PNS）、平滑肌收缩、内分泌疾病、神经退行性疾病、炎症、疼痛以及由化学物质滥用终止引起的戒断症状等多种疾病或障碍具有用处。
• Novel Azabicyclic Aryl Derivatives and Their Medical Use
  申请人：Peters Dan

  公开号：US20070299082A1

  公开（公告）日：2007-12-27

  This invention relates to novel azabicyclic aryl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  本发明涉及一种新型的氮杂双环芳基衍生物，发现它们是乙酰胆碱受体的胆碱能配体，并且是单胺类受体和转运体的调节剂。由于它们的药理特性，该发明的化合物可用于治疗与中枢神经系统（CNS）、外周神经系统（PNS）、平滑肌收缩相关的疾病或障碍、内分泌疾病或障碍、神经退行性疾病或障碍、炎症、疼痛以及化学物质滥用终止引起的戒断症状等多种疾病或障碍相关的疾病或障碍的治疗。
• ENANTIOPURE QUINUCLIDINYLOXY PYRIDAZINES AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS
  申请人：Peters Dan

  公开号：US20100227869A1

  公开（公告）日：2010-09-09

  This invention relates to novel enantiopure azabicyclo pyridazinyloxy derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  本发明涉及新型对映纯的氮杂双环吡啶啶氧衍生物，发现它们是乙酰胆碱受体的胆碱能配体，并且是单胺类受体和转运体的调节剂。由于它们的药理特性，本发明的化合物可能对治疗与中枢神经系统（CNS）和外周神经系统（PNS）的胆碱能系统相关的疾病或障碍，平滑肌收缩相关的疾病或障碍，内分泌疾病或障碍，神经退行性疾病或障碍，炎症、疼痛和由于滥用化学物质而引起的戒断症状等多种疾病或障碍有用。
• NOVEL AZABICYCLIC ARYL DERIVATIVES AND THEIR MEDICAL USE
  申请人：NeuroSearch A/S

  公开号：EP1802616B1

  公开（公告）日：2011-01-12
• US7652010B2
  申请人：——

  公开号：US7652010B2

  公开（公告）日：2010-01-26