1-methyl-3-(2-pyrazinyl)pyrrolidine | 125059-64-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-methyl-3-(2-pyrazinyl)pyrrolidine
• 英文别名: 2-(1-Methylpyrrolidin-3-yl)pyrazine
• CAS: 125059-64-5
• 化学式: C₉H₁₃N₃
• 分子量: 163.222
• InChiKey: VQHRCTKTXYZCMH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  29
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• PYRIDINE AND PYRIDIMINE COMPOUNDS AS PI3K-GAMMA INHIBITORS
  申请人：Incyte Corporation

  公开号：US20170190689A1

  公开（公告）日：2017-07-06

  The present disclosure provides compounds of Formula I, or pharmaceutically acceptable salts thereof, that modulate the activity of phosphoinositide 3-kinases-gamma (PI3Kγ) and are useful in the treatment of diseases related to the activity of PI3Kγ including, for example, autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

  本公开提供了化合物I的化合物，或其药用盐，其调节磷脂酰肌醇3-激酶-γ（PI3Kγ）的活性，并且在治疗与PI3Kγ活性相关的疾病方面具有用途，例如自身免疫疾病、癌症、心血管疾病和神经退行性疾病。
• Pyrazines, pyrimidines and pyridazines, useful in the treatment of senile dementia
  申请人：MERCK SHARP & DOHME LTD.

  公开号：EP0327155A2

  公开（公告）日：1989-08-09

  The present invention provides pyrazines, pyridazines or pyrimidines, or salts or prodrugs thereof, substituted on one of the ring carbon atoms therefore with a non-aromatic azacyclic or azabicyclic ring system; and independently substituted on each of the other ring carbon atoms with a substituent of low lipophilicity or a hydrocarbon substituent; which compounds stimulate central muscarinic acetylcholine receptors and therefore are useful in the treatment of neurological and mental illnesses.

  本发明提供吡嗪类、哒嗪类或嘧啶类化合物，或其盐类或原药，其中一个环碳原子被非芳族氮杂环或氮杂环环系取代；其他每个环碳原子分别独立地被低亲脂性取代基或烃类取代基取代；这些化合物可刺激中枢毒蕈碱乙酰胆碱受体，因此可用于治疗神经和精神疾病。
• Pyridine and pyridimine compounds as PI3K-gamma inhibitors
  申请人：Incyte Corporation

  公开号：US11352340B2

  公开（公告）日：2022-06-07

  The present disclosure provides compounds of Formula I, or pharmaceutically acceptable salts thereof, that modulate the activity of phosphoinositide 3-kinases-gamma (PI3Kγ) and are useful in the treatment of diseases related to the activity of PI3Kγ including, for example, autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

  本公开提供了式 I 的化合物或其药学上可接受的盐，它们能调节磷酸肌醇 3-激酶-γ（PI3Kγ）的活性，可用于治疗与 PI3Kγ 活性有关的疾病，例如包括自身免疫性疾病、癌症、心血管疾病和神经退行性疾病。
• METHOD FOR TREATING ANXIETY
  申请人：ELI LILLY AND COMPANY

  公开号：EP0783304A1

  公开（公告）日：1997-07-16
• EP0783304A4
  申请人：——

  公开号：EP0783304A4

  公开（公告）日：1999-01-27