1β,25-dihydroxyvitamin D2 | 98169-40-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 1β,25-dihydroxyvitamin D2
• 英文别名: 1beta,25-dihydroxyvitamin D2/1beta,25-dihydroxyergocalciferol；(1R,3R,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-6-hydroxy-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
• CAS: 98169-40-5
• 化学式: C₂₈H₄₄O₃
• 分子量: 428.656
• InChiKey: ZGLHBRQAEXKACO-COJHVNQMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  60.7
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• STABILIZED 1,25-DIHYDROXYVITAMIN D2 AND METHOD OF MAKING SAME
  申请人：Saha Uttam

  公开号：US20090233889A1

  公开（公告）日：2009-09-17

  A stabilized 1,25-dihydroxyvitamin D 2 composition which is particularly well suited for pharmaceutical formulations, pharmaceutical formulations of the 1,25-dihydroxyvitamin D 2 composition, and a method of making the purified composition by purifying a crude 1,25-dihydroxyvitamin D 2 from acetone/water, are disclosed.

  本发明公开了一种稳定的1,25-二羟基维生素D2组合物，特别适用于制药配方、1,25-二羟基维生素D2组合物的制药配方，并且通过从丙酮/水中纯化粗1,25-二羟基维生素D2来制备纯化组合物的方法。
• 1-Hydroxyvitamin D derivatives
  申请人：NISSHIN FLOUR MILLING CO., LTD.

  公开号：EP0506388A1

  公开（公告）日：1992-09-30

  1-Hydroxyvitamin D esters of vitamin A acid are useful for preventing and treating osteoporosis, cutaneous ulcer and tumour.

  维生素 A 酸的 1-羟基维生素 D 酯可用于预防和治疗骨质疏松症、皮肤溃疡和肿瘤。
• Stabilized 1, 25-Dihydroxyvitamin D2 and Method of Making Same
  申请人：CYTOCHROMA INC.

  公开号：US20140113886A1

  公开（公告）日：2014-04-24

  A stabilized 1,25-dihydroxyvitamin D 2 composition which is particularly well suited for pharmaceutical formulations, pharmaceutical formulations of the 1,25-dihydroxyvitamin D 2 composition, and a method of making the purified composition by purifying a crude 1,25-dihydroxyvitamin D 2 from acetone/water, are disclosed.
• US5182396A
  申请人：——

  公开号：US5182396A

  公开（公告）日：1993-01-26
• [EN] 1,25-DIHDROXYVITAMIN D2 COMPOUNDS AND METHODS FOR THEIR PREPARATION
  申请人：WISCONSIN ALUMNI RESEARCH FOUNDATION

  公开号：WO1985002189A1

  公开（公告）日：1985-05-23

  (EN) Preparation of hydroxylated compounds of the vitamin D2 series and specifically to a process for synthesizing 1alpha,25-dihydroxy vitamin D2, 1beta,25-dihydroxyvitamin D2, their corresponding 5,6-trans isomers and the C-24 epimers of these compounds. The hydroxylated vitamin D2 compounds obtained exhibit vitamin D-like activity and can be substituted for vitamin D3 or various of its known metabolites where such compounds are applied. (FR) Préparation de composés hydroxylés de la série de la vitamine D2 et procédé de synthèse de la 1alpha,25-dihydroxy-vitamine D2, 1beta,25-dihydroxy-vitamine D2, de leurs isomères correspondants 5,6-trans et des épimères à 24 C de ces composés. Les composés hydroxylés de vitamine D2 obtenus possèdent une activité similaire à celle de la vitamine D et peuvent remplacer la vitamine D3 ou plusieurs de ses métabolites connus lors de l'application de tels composés.