[5-(4-Fluoro-benzyloxy)-1,3-dioxo-1,3-dihydro-isoindol-2-yl]-4-methylsulfanyl-butyramide | 607735-08-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: [5-(4-Fluoro-benzyloxy)-1,3-dioxo-1,3-dihydro-isoindol-2-yl]-4-methylsulfanyl-butyramide
• 英文别名: (R,S)-[5-(4-fluoro-benzyloxy)-1,3-dioxo-1,3-dihydro-isoindol-2-yl]-4-methylsulfanyl-butyramide；2-[5-[(4-Fluorophenyl)methoxy]-1,3-dioxoisoindol-2-yl]-4-methylsulfanylbutanamide
• CAS: 607735-08-0
• 化学式: C₂₀H₁₉FN₂O₄S
• 分子量: 402.446
• InChiKey: GFEUZTOKTZBDEI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  115
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• PHTHALIMIDO DERIVATIVES AND A PROCESS FOR THEIR PREPARATION
  申请人：——

  公开号：US20030195208A1

  公开（公告）日：2003-10-16

  This invention relates to phthalimido derivatives of the formula 1 wherein X is —N═ or —CH═, and R 1 to R 4 and m are as defined in the specification, as well as their pharmaceutically acceptable salts. The invention further relates to pharmaceutical compositions containing these compounds, a method of treating a disease by administering a therapeutically effective amount of at least one of these compounds, and a process for their preparation for the treatment or prevention of diseases in which MAO-B inhibitors might be beneficial.

  本发明涉及公式1的邻苯二甲酰亚胺衍生物，其中X为—N或—CH，R1至R4和m如规范中定义的那样，以及它们的药用盐。本发明还涉及含有这些化合物的药物组合物，通过给予至少一种这些化合物的治疗有效量来治疗疾病的方法，以及为治疗或预防可能受益于MAO-B抑制剂的疾病而制备这些化合物的过程。
• Phthalimido derivatives and a process for their preparation
  申请人：——

  公开号：US20040229871A1

  公开（公告）日：2004-11-18

  This invention relates to phthalimido derivatives of the formula 1 wherein X is —N═ or —CH═, and R 1 to R 4 and m are as defined in the specification, as well as their pharmaceutically acceptable salts. The invention further relates to pharmaceutical compositions containing these compounds, a method of treating a disease by administering a therapeutically effective amount of at least one of these compounds, and a process for their preparation for the treatment or prevention of diseases in which MAO-B inhibitors might be beneficial.

  本发明涉及如下式1的邻苯二甲酰亚胺衍生物：其中X为—N═或—CH═，R1至R4和m的定义如规范中所示，以及其药学上可接受的盐。本发明还涉及含有这些化合物的制药组合物，通过给予至少一种这些化合物的治疗有效剂量来治疗疾病的方法，以及为治疗或预防可能受益于MAO-B抑制剂的疾病而制备这些化合物的过程。
• US6660736B2
  申请人：——

  公开号：US6660736B2

  公开（公告）日：2003-12-09
• US6903095B2
  申请人：——

  公开号：US6903095B2

  公开（公告）日：2005-06-07