(4R)-4-[(1R,3aS,3bR,9aS,9bS,11aR)-4,7,11-Trihydroxy-9a,11a-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]pentanoic acid | 130009-06-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (4R)-4-[(1R,3aS,3bR,9aS,9bS,11aR)-4,7,11-Trihydroxy-9a,11a-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]pentanoic acid
• 英文别名: (4R)-4-[(8R,9S,10S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
• CAS: 130009-06-2
• 化学式: C₂₄H₄₀O₅
• 分子量: 408.6
• InChiKey: BHQCQFFYRZLCQQ-IDYXOZSLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  98
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• [EN] PRODRUG BIPYRIDYLAMINOPYRIDINES AS SYK INHIBITORS<br/>[FR] PROMÉDICAMENT BIPYRIDYLAMINOPYRIDINES EN TANT QU'INHIBITEURS DE SYK
  申请人：MERCK SHARP & DOHME

  公开号：WO2014074421A1

  公开（公告）日：2014-05-15

  The present invention provides compounds of Formula (I), which are prodrugs of trans-4-[(1R)-(6-[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexanecarboxylic acid, a potent inhibitor of Syk. The compounds are useful in the treatment and prevention of diseases mediated by the enzyme, such as asthma, COPD, rheumatoid arthritis and cancer.

  本发明提供了化合物的公式（I），这些化合物是trans-4-[(1R)-(6-[4-(二氟甲基)吡啶-2-基]氨基}-4-甲基-2,3'-联吡啶-6'-基)-1-羟乙基]环己烷羧酸的前药，是Syk的有效抑制剂。这些化合物在治疗和预防由该酶介导的疾病方面非常有用，如哮喘、慢性阻塞性肺病、类风湿性关节炎和癌症。
• SUBSTITUTED ARYL ONIUM MATERIALS
  申请人：Rohm and Haas Electronic Materials LLC

  公开号：US20150093708A1

  公开（公告）日：2015-04-02

  Acid generators comprising a carbocyclic or heteroaromatic group substituted with at least one diester moiety are provided. These acid generators are particularly useful as a photoresist composition component.

  提供了一种包含至少一个双酯基团取代的环烃或杂环芳基团的酸发生剂。这些酸发生剂特别适用于光刻胶组分。
• ARYL ACETATE ONIUM MATERIALS
  申请人：Rohm and Haas Electronic Materials LLC

  公开号：US20150093709A1

  公开（公告）日：2015-04-02

  Acid generators comprising a carbocyclic aryl or heteroaromatic group substituted with at least one acetate moiety are provided. These acid generators are particularly useful as a photoresist composition component.

  提供了一种包括至少一个乙酸基取代的环状芳基或杂环芳基的酸发生剂。这些酸发生剂在光刻胶组分中特别有用。
• Substituted aryl onium materials
  申请人：Rohm and Haas Electronic Materials LLC

  公开号：US10179778B2

  公开（公告）日：2019-01-15

  Acid generators comprising a carbocyclic or heteroaromatic group substituted with at least one diester moiety are provided. These acid generators are particularly useful as a photoresist composition component.

  提供了由至少一个二酯分子取代的碳环或杂芳族基团组成的酸生成物。这些酸生成物作为光阻组合物成分特别有用。
• Processes and host cells for genome, pathway, and biomolecular engineering
  申请人：enEvolv, Inc.

  公开号：US10370654B2

  公开（公告）日：2019-08-06

  The present disclosure provides compositions and methods for genomic engineering.

  本公开提供了基因组工程的组合物和方法。