4-环己基-2-丁胺 | 791752-94-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 4-环己基-2-丁胺
• 中文别名: 4-环己基丁烷-2-胺
• 英文名称: 4-cyclohexyl-2-butanamine hydrochloride
• 英文别名: 4-cyclohexylbutan-2-amine
• CAS: 791752-94-8
• 化学式: C₁₀H₂₁N
• 分子量: 155.283
• InChiKey: PGKIYCIVGXRFTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-环己基-2-丁胺 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 2.25h， 生成 N-[N-(4-cyclohexylbutan-2-yl)-N'-[3-(1H-imidazol-5-yl)propyl]carbamimidoyl]benzamide
  参考文献：
  名称：

  Synthesis and histamine H2 agonistic activity of arpromidine analogues: replacement of the pheniramine-like moiety by non-heterocyclic groups

  摘要：

  Analogues of the potent histamine H-2 agonist arpromidine, characterized by non-heterocyclic groups (phenyl, cyclo-hexyl, alkyl) instead of the pheniramine-like portion, were prepared and tested for their H-2 agonistic and H-1 antagonistic activity in the isolated guinea pig right atrium and ileum, respectively. In the diphenylpropylguanidine series an increase in H-2 agonistic potency resulted from mono- or difluorination at one or both phenyl rings in the meta and/or para position (pD2 less-than-or-equal-to 7.75 vs pD2 = 7.15 for the unsubstituted parent compound). Compounds chlorinated at both phenyl rings were considerably less potent. Highest combined H-2 agonistic/H-1 antagonistic potency was found in the 4-fluorophenyl series. The arpromidine analogue with cyclohexyl and methyl group instead of phenyl and pyridine ring proved to be 30 times more potent than histamine in the atrium. The H-1 antagonistic potency in cyclohexyl compounds was lower than in the diaryl series. Thus, aromatic rings appear not to be required for high H-2 agonistic potency but are useful for combined H-2 agonistic/H-1 antagonistic activity.

  DOI：

  10.1016/0223-5234(92)90145-q
• 作为产物：
  描述：

  2-(3-cyclohexyl-1-methylpropyl)-1H-isoindole-1,3(2H)-dione 在 肼 作用下， 以 乙醇 为溶剂， 以37%的产率得到4-环己基-2-丁胺
  参考文献：
  名称：

  New N-alkyl-heterocyclyl carboxamide derivatives

  摘要：

  通式（I）的化合物：制备这种化合物的方法。通式（II）的化合物。包含通式（I）的杀真菌剂组合物。通过应用通式（I）或包含它的组合物来处理植物的方法。

  公开号：

  EP1772449A1

文献信息

• Process for the preparation of benzothiazole-2-sulphenamides
  申请人：MONSANTO EUROPE S.A.

  公开号：EP0314663A1

  公开（公告）日：1989-05-03

  In a process for the production of benzothiazole-2-sulphenamides, a 2-mercaptobenzothiazole in the form of a particulate solid or a dispersion of a particulate solid in a liquid carrier is added gradually and concurrently with an aqueous solution of sodium hypochlorite to a solution of an amine in a mixture of water and a water-miscible organic solvent, the amount of amine being not more than 1.25 moles per mole of 2-mercaptobenzothiazole. A feature of the process is that it represents a significant improvement over prior art methods for the production of sulphenamides derived from secondary amines such as dicyclohexylamine and diisopropylamine.

  在生产苯并噻唑-2-磺胺类化合物的过程中，将2-巯基苯并噻唑以颗粒固体或颗粒固体在液体载体中的分散形式逐渐加入并与次氯酸钠的水溶液同时加入到胺类化合物在水和水溶性有机溶剂混合物中的溶液中，胺类化合物的量不超过每摩尔2-巯基苯并噻唑的1.25摩尔。该过程的特点是，它相对于以二环己胺和二异丙胺等二级胺为原料生产磺胺类化合物的先前方法表示了显著的改进。
• N-Alkyl-Heterocyclyl Carboxamide Derivatives
  申请人：Mansfield Darren

  公开号：US20100197633A1

  公开（公告）日：2010-08-05

  A compound of general formula (I): A process for preparing this compound. A compound of general formula (II) A fungicide composition comprising a compound of general formula (I). A method for treating plants by applying a compound of general formula (I) or a composition comprising it.

  一个通用式为(I)的化合物：制备该化合物的方法。 一个通用式为(II)的化合物。 一种包含通式为(I)的化合物的杀菌剂组合物。 一种通过应用通式为(I)的化合物或包含该化合物的组合物来处理植物的方法。
• N-alkyl-heterocyclyl carboxamide derivatives
  申请人：Bayer Cropscience AG

  公开号：US08148538B2

  公开（公告）日：2012-04-03

  A compound of general formula (I): A process for preparing this compound. A compound of general formula (II) A fungicide composition comprising a compound of general formula (I). A method for treating plants by applying a compound of general formula (I) or a composition comprising it.

  一种通式为(I)的化合物；制备该化合物的方法；一种通式为(II)的化合物；一种包含通式为(I)的化合物的杀菌剂组合物；一种通过应用通式为(I)的化合物或包含该化合物的组合物来处理植物的方法。
• NEW N-ALKYL-HETEROCYCLYL CARBOXAMIDE DERIVATIVES
  申请人：Bayer CropScience AG

  公开号：EP1937637B1

  公开（公告）日：2013-04-03
• NEW COMPOUNDS AND PHARMACEUTICAL USE THEREOF IN THE TREATMENT OF CANCER
  申请人：INSERM (Institut National de la Santé et de la Recherche Médicale)

  公开号：EP3454879B1

  公开（公告）日：2021-12-22