phenyl N-(2,1,3-benzothiadiazol-4-yl)carbamate | 934555-23-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻二唑类
• 英文名称: phenyl N-(2,1,3-benzothiadiazol-4-yl)carbamate
• CAS: 934555-23-4
• 化学式: C₁₃H₉N₃O₂S
• 分子量: 271.299
• InChiKey: ROXPBIKSBDOHTN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  92.4
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-苯基-5-哌嗪基-1,2,4-噻二唑 、 phenyl N-(2,1,3-benzothiadiazol-4-yl)carbamate 以 二甲基亚砜 为溶剂， 以85%的产率得到N-(benzo[c][1,2,5]thiadiazol-4-yl)-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
  参考文献：
  名称：

  Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase

  摘要：

  A series of thiadiazolopiperazinyl aryl urea fatty acid amide hydrolase ( FAAH) inhibitors is described. The molecules were found to inhibit the enzyme by acting as mechanism-based substrates, forming a covalent bond with Ser241. SAR and PK properties are presented. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.07.081
• 作为产物：
  描述：

  4-氨基-2,1,3-苯并噻二唑 、 氯甲酸苯酯 以38%的产率得到phenyl N-(2,1,3-benzothiadiazol-4-yl)carbamate
  参考文献：
  名称：

  Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase

  摘要：

  A series of thiadiazolopiperazinyl aryl urea fatty acid amide hydrolase ( FAAH) inhibitors is described. The molecules were found to inhibit the enzyme by acting as mechanism-based substrates, forming a covalent bond with Ser241. SAR and PK properties are presented. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.07.081

文献信息

• Substituted Benzofused Derivatives and Their Use as Vanilloid Receptor Ligands
  申请人：Gharat Laxmikant Atmaram

  公开号：US20080269253A1

  公开（公告）日：2008-10-30

  The present invention relates to substituted benzofused derivatives, which can be used as vanilloid receptor ligands, method of treating diseases, conditions and/or disorders modulated by vanilloid receptors with them, and processes for preparing them.

  本发明涉及取代苯并衍生物，可以用作vanilloid受体配体，用它们治疗受vanilloid受体调节的疾病、情况和/或疾患的方法，以及制备它们的过程。
• SUBSTITUTED BENZOFUSED DERIVATIVES AND THEIR USE AS VANILLOID RECEPTOR LIGANDS
  申请人：GHARAT Laxmikant Atmaram

  公开号：US20120041011A1

  公开（公告）日：2012-02-16

  The present invention relates to substituted benzofused derivatives, which can he used as vanilloid receptor ligands, method of treating diseases, conditions and/or disorders modulated by vanilloid receptors with them, and processes for preparing them.

  本发明涉及取代苯并衍生物，可用作vanilloid受体配体，用于治疗由vanilloid受体调节的疾病、状况和/或障碍的方法，以及制备它们的过程。
• US7842703B2
  申请人：——

  公开号：US7842703B2

  公开（公告）日：2010-11-30
• [EN] SUBSTITUTED BENZOFUSED DERIVATIVES AND THEIR USE AS VANILLOID RECEPTOR LIGANDS<br/>[FR] DÉRIVÉS BENZOFUSIONNÉS SUBSTITUÉS ET LEUR UTILISATION EN TANT QUE LIGANDS DES RÉCEPTEURS VANILLOÏDES
  申请人：GLENMARK PHARMACEUTICALS SA

  公开号：WO2007042906A1

  公开（公告）日：2007-04-19

  [EN] The present invention relates to substituted benzofused derivatives, which can be used as vanilloid receptor ligands, method of treating diseases, conditions and/or disorders modulated by vanilloid receptors with them, and processes for preparing them.
  [FR] La présente invention concerne des dérivés benzofusionnés substitués qui peuvent être utilisés en tant que ligands des récepteurs vanilloïdes. L'invention concerne également un procédé de traitement à l'aide desdits dérivés de maladies, d'états et/ou de troubles modulés par les récepteurs vanilloïdes, ainsi que des procédés de préparation desdits dérivés.
• Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase
  作者：John M. Keith、Richard Apodaca、Wei Xiao、Mark Seierstad、Kanaka Pattabiraman、Jiejun Wu、Michael Webb、Mark J. Karbarz、Sean Brown、Sandy Wilson、Brian Scott、Chui-Se Tham、Lin Luo、James Palmer、Michelle Wennerholm、Sandra Chaplan、J. Guy Breitenbucher

  DOI：10.1016/j.bmcl.2008.07.081

  日期：2008.9

  A series of thiadiazolopiperazinyl aryl urea fatty acid amide hydrolase ( FAAH) inhibitors is described. The molecules were found to inhibit the enzyme by acting as mechanism-based substrates, forming a covalent bond with Ser241. SAR and PK properties are presented. (C) 2008 Elsevier Ltd. All rights reserved.