(E)-11-chloro-N'-(2,2,2-trifluoroethyl)dibenzo[b,f][1,4]thiazepine-8-carbohydrazide | 1020412-74-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并硫氮卓类
• 英文名称: (E)-11-chloro-N'-(2,2,2-trifluoroethyl)dibenzo[b,f][1,4]thiazepine-8-carbohydrazide
• 英文别名: 6-chloro-N'-(2,2,2-trifluoroethyl)benzo[b][1,4]benzothiazepine-3-carbohydrazide
• CAS: 1020412-74-1
• 化学式: C₁₆H₁₁ClF₃N₃OS
• 分子量: 385.797
• InChiKey: ADHPAJLVPYONSP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  78.8
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• CB-1 MODULATING COMPOUNDS AND THEIR USE
  申请人：Olsson Roger

  公开号：US20080090805A1

  公开（公告）日：2008-04-17

  Disclosed herein is a compound of Formula (I). Also disclosed herein is a method of modulating the activity of a cannabinoid receptor using a compound of Formula (I). Furthermore, disclosed herein is a method of treating a disease or condition that would be alleviated, improved or prevented by administration of a compound that modulates a cannabinoid receptor comprising identifying a subject in need thereof and administering to said subject a therapeutically effective amount of a compound of Formula (I). Also disclosed herein are pharmaceutical compositions comprising a compound of Formula (I).

  本文披露了一种化合物的结构式(I)。同时也披露了使用结构式(I)的化合物调节大麻素受体活性的方法。此外，还披露了一种治疗疾病或症状的方法，该疾病或症状可以通过给予调节大麻素受体的化合物得到缓解、改善或预防，包括确定需要该方法的受试者，并向该受试者施用结构式(I)的化合物的治疗有效量。本文还披露了包含结构式(I)的药物组合物。
• Novel Acetylcholinesterase Gene Responsible for Insecticide Resistance and Applications Thereof
  申请人：Weill Mylene

  公开号：US20080256649A1

  公开（公告）日：2008-10-16

  The invention relates to a novel acetylcholinesterase gene (ace-1) responsible for resistance to organophosphorus and/or carbamates in mosquitoes, which is non-homologous to the D. melanogaster acetylcholinesterase gene (ace-2), products of the ace-1 gene (cDNA, protein AchE1) and the applications thereof, particularly for the screening of novel insecticides and the genetic detection of resistance to organophosphorus and/or carbamates in mosquito populations.
• US8198061B2
  申请人：——

  公开号：US8198061B2

  公开（公告）日：2012-06-12