2-cyano-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine | 852291-39-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-cyano-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine
• 英文别名: 5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carbonitrile
• CAS: 852291-39-5
• 化学式: C₈H₉N₃S
• 分子量: 179.246
• InChiKey: MVTBVJBFECSGCI-UHFFFAOYSA-N

物化性质

• 沸点：
  308.4±34.0 °C(Predicted)
• 密度：
  1.31±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  68.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-cyano-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine hydrochloride 在 碳酸氢钠 作用下， 以 水 为溶剂， 生成 2-cyano-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine
  参考文献：
  名称：

  EP1683800

  摘要：

  公开号：

文献信息

• PROCESS FOR PRODUCING 5-METHYL-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-c]PYRIDINE-2-CARBOXYLIC ACID
  申请人：NAGASAWA Hiroshi

  公开号：US20090192313A1

  公开（公告）日：2009-07-30

  5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid of formula (5) or a salt thereof, [F14] is prepared by reacting a compound of formula (6) or a salt thereof, with a trihalogenoacetyl halide in the presence of a base, followed by hydrolysis.

  化合物5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid或其盐[F14]的制备方法为，在碱存在下，将化合物式为(6)或其盐与三卤代乙酰卤反应，然后进行水解。
• Process for producing thiazole derivative
  申请人：Nagasawa Hiroshi

  公开号：US20070135476A1

  公开（公告）日：2007-06-14

  The present invention provides processes for producing a compound (5) based on the following reaction scheme.

  本发明提供了基于以下反应方程式生产化合物（5）的工艺过程。
• Process for producing 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid
  申请人：Daiichi Sankyo Company, Limited

  公开号：US08058440B2

  公开（公告）日：2011-11-15

  5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid of formula (5) or a salt thereof, is prepared by reacting reacting 2-bromo-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine of formula (3) or a salt thereof, with a metal cyanide, to obtain 2-cyano-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine of formula (4) or a salt thereof, and hydrolyzing the 2-cyano-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine of formula (4) or a salt thereof.

  化合物5-甲基-4,5,6,7-四氢噻唑并[5,4-c]吡啶-2-羧酸（化学式（5））或其盐，是通过将化合物2-溴-5-甲基-4,5,6,7-四氢噻唑并[5,4-c]吡啶（化学式（3））或其盐与金属氰化物反应，得到化合物2-氰基-5-甲基-4,5,6,7-四氢噻唑并[5,4-c]吡啶（化学式（4））或其盐，然后水解化合物2-氰基-5-甲基-4,5,6,7-四氢噻唑并[5,4-c]吡啶（化学式（4））或其盐而制备得到的。
• Process for producing 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]Pyridine-2-carboxylic acid
  申请人：Daiichi Sankyo Company, Limited

  公开号：US07678910B2

  公开（公告）日：2010-03-16

  5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid of formula (5) or a salt thereof, [F14] is prepared by reacting a compound of formula (6) or a salt thereof, with a trihalogenoacetyl halide in the presence of a base, followed by hydrolysis.

  化合物5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid（式子为（5））或其盐，[F14]是通过在碱存在下，将化合物式子为（6）或其盐与三卤代乙酰卤反应，然后进行水解制备而来的。
• PROCESS FOR PRODUCING THIAZOLE DERIVATIVE
  申请人：DAIICHI PHARMACEUTICAL CO., LTD.

  公开号：EP1683800A1

  公开（公告）日：2006-07-26

  The present invention provides processes for producing a compound (5) based on the following reaction scheme. [F1]

  本发明提供了基于以下反应方案生产化合物（5）的工艺。 [F1]