3,7-Dihydro-2,6-dimethylimidoazo<1,2-a>pyrazin-3-on | 28036-42-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡嗪类
• 英文名称: 3,7-Dihydro-2,6-dimethylimidoazo<1,2-a>pyrazin-3-on
• 英文别名: 2,6-dimethyl-7H-imidazo[1,2-a]pyrazin-3-one
• CAS: 28036-42-2
• 化学式: C₈H₉N₃O
• 分子量: 163.179
• InChiKey: FHNBYDGIEZDVKA-UHFFFAOYSA-N

文献信息

• [EN] CHEMILUMINESCENT PROBES<br/>[FR] SONDES CHIMIOLUMINESCENTES
  申请人：MASSACHUSETTS GEN HOSPITAL

  公开号：WO2021155190A1

  公开（公告）日：2021-08-05

  The present application provides a compound of Formula (I): A-L-B (I), or a pharmaceutically acceptable salt thereof, wherein A, L, and B are as described herein. Compositions comprising the compounds of Formula (I) (and optionally a fluorescent probe) are also provided, as well as the methods of (i) using the compound of formula (I) for identifying a misfolding-prone or an aggregating-prone protein in a sample, (ii) determining concentration of a misfolding-prone or an aggregating-prone protein in a sample, (iii) imaging an organ or tissue comprising a misfolding-prone or an aggregating-prone protein in a subject, (iv) diagnosing or monitoring treatment of a disease or condition associsated with a misfolding-prone or an aggregating-prone protein in a subject, and (v) diagnosing a disease or condition characterized by accumulation of misfolding-prone or aggregation-prone peptides or proteins in a blood of a subject.

  本申请提供了化合物公式（I）的化合物：A-L-B（I），或其药学上可接受的盐，其中A、L和B如此处所述。还提供了包含公式（I）化合物（和可选的荧光探针）的组合物，以及以下方法：（i）使用公式（I）化合物在样品中识别易于错误折叠或聚集的蛋白质，（ii）确定样品中易于错误折叠或聚集的蛋白质的浓度，（iii）成像包含易于错误折叠或聚集的蛋白质的器官或组织在受试者中，（iv）诊断或监测与易于错误折叠或聚集的蛋白质相关的疾病或病况的治疗，以及（v）诊断一种以易于错误折叠或聚集的肽或蛋白质在受试者血液中积累为特征的疾病或病况。