4-甲基-1-(1-苯基环己基)哌啶盐酸盐 | 2201-42-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 4-甲基-1-(1-苯基环己基)哌啶盐酸盐
• 英文名称: 4-Methyl-1-<1-phenyl-cyclohexyl>-piperidin
• 英文别名: 1-(1-phenylcyclohexyl)-4-methylpiperidine；4-methyl-1-(1-phenyl-cyclohexyl)-piperidine；4-methyl-1-(1-phenylcyclohexyl)piperidine
• CAS: 2201-42-5
• 化学式: C₁₈H₂₇N
• 分子量: 257.419
• InChiKey: AJUVHIRWTCUZLT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2933399090

反应信息

• 作为产物：
  描述：

  1-(4-Methyl-piperidin-1-yl)-cyclohexanecarbonitrile 生成 4-甲基-1-(1-苯基环己基)哌啶盐酸盐
  参考文献：
  名称：

  KAMENKA, JEAN-MARC;PRIVAT, ALAIN;CHICHEPORTICHE, ROBERT RUBIN;ROUDOUIN, G+

  摘要：

  DOI：

文献信息

• Synthesis and Preliminary Biochemical Evaluation of Novel Derivatives of PCP
  作者：Joannes Linders、David Furlano、Mariena Mattson、Arthur Jacobson、Kenner Rice

  DOI：10.2174/157018010790225813

  日期：2010.2.1

  (±)-Trans-Ph/Et and (±)-cis-Ph/Et 1-(2-ethyl-1-phenylcyclohexyl)piperidine were synthesized from 2-ethylcyclohexanone. In contrast to the corresponding trans-substituted 2-methyl compound which is 5x more potent than PCP, the trans-2-ethyl derivative has a 75x lower affinity for the PCP binding site. The cis-2-ethyl isomer is inactive like the cis-2-methyl derivative. (±)-1-(1- Phenylcyclohexyl)-2-methylpiperidine is almost as active as the parent PCP. Reduction of the aromatic ring or quaternization of the piperidine in PCP reduces the affinity for the PCP site.

  (±)-Trans-Ph/Et 和 (±)-cis-Ph/Et 1-(2-乙基-1-苯基环己基)哌啶是从2-乙基环己酮合成的。与相应的trans-取代的2-甲基化合物相比，其效力是PCP的5倍，而trans-2-乙基衍生物对PCP结合位点的亲和力降低了75倍。cis-2-乙基异构体与cis-2-甲基衍生物一样不活跃。(±)-1-(1-苯基环己基)-2-甲基哌啶的活性几乎与母体PCP相当。对PCP中的芳环进行还原或对哌啶进行季铵化会降低其对PCP位点的亲和力。
• Method for treating nervous system disorders and conditions
  申请人：Abou-Gharbia A. Magid

  公开号：US20060020014A1

  公开（公告）日：2006-01-26

  The present invention is directed to racemic 1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, racemic 1-(4-methylphenyl)-3-azabicyclo[3.1.0]hexane, and (+)-1-(4-methylphenyl)-3-azabicyclo[3.1.0]hexane, and methods of their use for treating certain nervous system disorders and conditions, including, inter alia, vasomotor symptoms (VMS) and chronic pain.

  本发明涉及外消旋1-(3,4-二氯苯基)-3-氮杂双环[3.1.0]己烷、(+)-1-(3,4-二氯苯基)-3-氮杂双环[3.1.0]己烷、外消旋1-(4-甲基苯基)-3-氮杂双环[3.1.0]己烷和(+)-1-(4-甲基苯基)-3-氮杂双环[3.1.0]己烷，以及它们用于治疗某些神经系统障碍和病症的方法，包括血管运动症状（VMS）和慢性疼痛等。
• METHOD FOR TREATING NERVOUS SYSTEM DISORDERS AND CONDITIONS
  申请人：Abou-Gharbia Magid A.

  公开号：US20120190721A1

  公开（公告）日：2012-07-26

  The present invention is directed to racemic 1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, racemic 1-(4-methylphenyl)-3-azabicyclo[3.1.0]hexane, and (+)-1-(4-methylphenyl)-3-azabicyclo[3.1.0]hexane, and methods of their use for treating certain nervous system disorders and conditions, including, inter alia, vasomotor symptoms (VMS) and chronic pain.

  本发明涉及外消旋1-(3,4-二氯苯基)-3-氮杂双环[3.1.0]己烷、(+)-1-(3,4-二氯苯基)-3-氮杂双环[3.1.0]己烷、外消旋1-(4-甲基苯基)-3-氮杂双环[3.1.0]己烷和(+)-1-(4-甲基苯基)-3-氮杂双环[3.1.0]己烷，以及它们治疗某些神经系统疾病和病况的方法，包括血管运动症状（VMS）和慢性疼痛等。
• [EN] METHOD FOR TREATING NERVOUS SYSTEM DISORDERS AND CONDITIONS<br/>[FR] PROCEDE DE TRAITEMENT DE PATHOLOGIES ET DE TROUBLES DU SYSTEME NERVEUX
  申请人：WYETH CORP

  公开号：WO2006012477A1

  公开（公告）日：2006-02-02

  The present invention is directed to racemic 1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, racemic 1-(4-methylphenyl)-3-azabicyclo[3.1.0]hexane, and (+)-1-(4-methylphenyl)-3-azabicyclo[3.1.0]hexane, and methods of their use for treating certain nervous system disorders and conditions, including, inter alia, vasomotor symptoms (VMS) and chronic pain.