2-(5`-氯-2`-膦酰苯基)-6-氯-4(3H)-喹唑酮 | 147394-94-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 中文名称: 2-(5`-氯-2`-膦酰苯基)-6-氯-4(3H)-喹唑酮
• 中文别名: ELF97磷酸酯；[4-氯-2-(6-氯-4-氧代-1H-喹唑啉-2-基)苯基]磷酸二氢酯
• 英文名称: 2-(5'-chloro-2'-phosphoryloxyphenyl)-6-chloro-4-(3H)-quinazolinone
• 英文别名: [4-chloro-2-(6-chloro-4-oxo-3H-quinazolin-2-yl)phenyl] dihydrogen phosphate
• CAS: 147394-94-3
• 化学式: C₁₄H₉Cl₂N₂O₅P
• 分子量: 387.116
• InChiKey: IXZONVAEGFOVSF-UHFFFAOYSA-N

物化性质

• 沸点：
  654.9±65.0 °C(Predicted)
• 密度：
  1.78±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  108
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-(5'-chloro-2'-di-t-butylphosphoryloxyphenyl)-6-chloro-4-(3H)-quinazolinone 在 盐酸 作用下， 以 1,4-二氧六环 为溶剂， 生成 2-(5`-氯-2`-膦酰苯基)-6-氯-4(3H)-喹唑酮
  参考文献：
  名称：

  新型荧光沉淀底物的合成与应用

  摘要：

  已经制备了新的荧光酯酶，糖苷酶，芳基硫酸酯酶，微粒体脱烷基酶，胍基苯甲酰酶和碱性磷酸酶底物，其在体外和体内都沉淀在酶活性的位点。

  DOI：

  10.1016/s0040-4039(00)78438-3

文献信息

• Process for the immobilization of proteins on an implant
  申请人：Jennissen, Herbert P., Prof. Dr.

  公开号：EP1880739A1

  公开（公告）日：2008-01-23

  The present invention refers to the chemical functionalisation of surfaces, in particular ceramic materials, particularly such comprising hydroxyapatite, and the use of tensides for improving the absorption characteristics of metallic or ceramic surfaces.

  本发明涉及表面的化学功能化，特别是陶瓷材料，尤其是由羟基磷灰石组成的陶瓷材料，以及使用张量剂改善金属或陶瓷表面的吸收特性。
• Method for identifying compounds modulating adiponectin gene expression
  申请人：Zeltia, S.A.

  公开号：EP2020447A1

  公开（公告）日：2009-02-04

  The invention relates to a method for identifying suitable compounds for the treatment and/or prevention of metabolic diseases in which there are altered adiponectin levels, which method uses reporter cell systems containing DNA constructs comprising the adiponectin gene promoter region operatively coupled to a reporter gene and in which the compounds causing an alteration in the reporter gene expression form candidates that are useful in the treatment or prevention of said metabolic diseases.

  本发明涉及一种用于鉴定治疗和/或预防代谢性疾病的合适化合物的方法，在这种代谢性疾病中，脂肪连通素水平会发生改变，该方法使用含有 DNA 构建物的报告细胞系统，该 DNA 构建物包含与报告基因操作耦合的脂肪连通素基因启动子区，在该系统中，导致报告基因表达改变的化合物形成了可用于治疗或预防所述代谢性疾病的候选化合物。
• High sensitivty immunoassays and kits for the determination of peptides and proteins of biological interest
  申请人：Araclon Biotech

  公开号：EP2020602A1

  公开（公告）日：2009-02-04

  The invention relates to immunoassays which allow the detection of polypeptides in samples with a higher sensitivity than assays of the state of the art. The invention also relates to kits which provide the components needed for carrying out said immunoassays.

  本发明涉及免疫测定法，该方法可以检测样品中的多肽，其灵敏度高于现有技术。本发明还涉及提供进行上述免疫测定所需成分的试剂盒。
• DUAL-RECOGNITION IMMUNOASSAY FOR THE DETECTION OF ANTIBODIES
  申请人：INMUNOLOGIA Y GENETICA APLICADA, S.A.

  公开号：EP2184605A1

  公开（公告）日：2010-05-12

  The invention relates to a dual-recognition immunoassay for the detection of antibodies specific to a target antigen in a sample which comprises contacting said target antigen with a sample suspected of containing said antibodies specific to said target antigen under conditions allowing the formation of an antigen-antibody complex; adding a conjugate comprising said target antigen and a marker under conditions allowing the formation of an antigen-antibody-antigen/marker complex; and detecting said antigen-antibody-antigen/marker complex. The immunoassay can be used, among other applications, in the diagnosis of infections caused by pathogenic organisms with high sensitivity and specificity.

  本发明涉及一种用于检测样品中目标抗原特异性抗体的双重识别免疫分析法，该方法包括在允许形成抗原-抗体复合物的条件下，将所述目标抗原与疑似含有所述目标抗原特异性抗体的样品接触；在允许形成抗原-抗体-抗原/标记复合物的条件下，加入由所述目标抗原和标记物组成的共轭物；以及检测所述抗原-抗体-抗原/标记复合物。除其他应用外，该免疫测定法还可用于诊断由病原体引起的感染，并具有高灵敏度和特异性。
• METHOD OF IDENTIFYING COMPOUNDS THAT INDUCE OR INHIBIT ENDOPLASMIC RETICULUM STRESS OR OXIDATIVE STRESS
  申请人：Universidad Autónoma de Madrid

  公开号：EP2221379A1

  公开（公告）日：2010-08-25

  The present invention generally relates to a method for the identification of compounds for the treatment of neurodegenerative diseases. Said method is based on a cell model for neurodegeneration useful for the identification of potentially useful compounds for the treatment or the prevention of a neurodegenerative disease associated with deficient expression of the DDIT3 gene, also known as CHOP.

  本发明一般涉及一种鉴定用于治疗神经退行性疾病的化合物的方法。该方法基于一种神经变性细胞模型，用于鉴定治疗或预防与 DDIT3 基因（又称 CHOP）表达缺陷有关的神经变性疾病的潜在有用化合物。