(1, 1-dimethyl-2-(4-oxo-5-(2'-(N-triphenylmethyltetrazol-5-yl)biphenyl-4-ylmethyl)-2,3,4,5-tetrahydro-1H-naphtho[2,1-b]azepin-3-ylcarbamoyl)ethyl)-carbamic acid tert-butyl ester | 178201-83-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: (1, 1-dimethyl-2-(4-oxo-5-(2'-(N-triphenylmethyltetrazol-5-yl)biphenyl-4-ylmethyl)-2,3,4,5-tetrahydro-1H-naphtho[2,1-b]azepin-3-ylcarbamoyl)ethyl)-carbamic acid tert-butyl ester
• 英文别名: (1,1-dimethyl-2-(4-oxo-5-(2'-(N-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl)-2,3,4,5-tetrahydronaphtho[2,1-b]azepin-3-ylcarbamoyl)ethyl)carbamic acid tert-butyl ester；tert-butyl N-[2-methyl-4-oxo-4-[[4-oxo-5-[[4-[2-(1-trityltetrazol-5-yl)phenyl]phenyl]methyl]-2,3-dihydro-1H-benzo[g][1]benzazepin-3-yl]amino]butan-2-yl]carbamate
• CAS: 178201-83-7
• 化学式: C₅₇H₅₅N₇O₄
• 分子量: 902.108
• InChiKey: PMRIAPKHCNZGAF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.8
• 重原子数：
  68
• 可旋转键数：
  14
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  131
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  (1, 1-dimethyl-2-(4-oxo-5-(2'-(N-triphenylmethyltetrazol-5-yl)biphenyl-4-ylmethyl)-2,3,4,5-tetrahydro-1H-naphtho[2,1-b]azepin-3-ylcarbamoyl)ethyl)-carbamic acid tert-butyl ester 在 盐酸 作用下， 以 乙酸乙酯 为溶剂， 生成 3-amino-3-methyl-N-[4-oxo-5-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-2,3-dihydro-1H-benzo[g][1]benzazepin-3-yl]butanamide
  参考文献：
  名称：

  Naphtho-fused azepines as potent growth hormone secretagogues

  摘要：

  Computerguided improvements of known growth hormone secretagogues are reported. These are a new series of napthofused azepines. Structure-activity relationships are different than in the corresponding benzo-fused azepines. (C) 1997 Eisevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)10115-9
• 作为产物：
  描述：

  3,4-二氢-2H-菲-1-酮 在 氢氧化钾 、 三甲基氯硅烷 、 甲烷磺酸 、 氨 、 羟胺 、 碘 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 sodium iodide 作用下， 以 甲醇 、 二甲基亚砜 为溶剂， 生成 (1, 1-dimethyl-2-(4-oxo-5-(2'-(N-triphenylmethyltetrazol-5-yl)biphenyl-4-ylmethyl)-2,3,4,5-tetrahydro-1H-naphtho[2,1-b]azepin-3-ylcarbamoyl)ethyl)-carbamic acid tert-butyl ester
  参考文献：
  名称：

  Naphtho-fused azepines as potent growth hormone secretagogues

  摘要：

  Computerguided improvements of known growth hormone secretagogues are reported. These are a new series of napthofused azepines. Structure-activity relationships are different than in the corresponding benzo-fused azepines. (C) 1997 Eisevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)10115-9

文献信息

• N-substituted naphthofused lactams
  申请人：Novo Nordisk A/S

  公开号：US05817654A1

  公开（公告）日：1998-10-06

  The present invention relates to novel N-substituted naphthofused lactams and salts thereof of the formula ##STR1## Compounds of the general formula I possess the ability to stimulate the release of endogenous growth hormone. Thus, these compounds may be used in the treatment of conditions which require stimulation of growth hormone production or secretion such as in humans with growth hormone deficiency or where increased growth hormone plasma levels are desired, for instance in elderly patients or in livestock.

  本发明涉及新型N-取代的萘并噁唑内酰胺及其盐，化学式如下：化合物的一般式I具有刺激内源性生长激素释放的能力。因此，这些化合物可用于治疗需要刺激生长激素产生或分泌的病症，例如对于生长激素缺乏症或需要增加生长激素血浆水平的人类，例如老年患者或家畜。
• US5817654A
  申请人：——

  公开号：US5817654A

  公开（公告）日：1998-10-06