(1-Amino-2-hydroxyheptan-2-yl)phosphonic acid | 54899-49-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: (1-Amino-2-hydroxyheptan-2-yl)phosphonic acid
• CAS: 54899-49-9
• 化学式: C₇H₁₈NO₄P
• 分子量: 211.198
• InChiKey: OKUONIVIUHQJKB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.2
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  104
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  Di-isopropyl-1-hydroxy-1-pentyl-2-nitroethylphosphonat 生成 (1-Amino-2-hydroxyheptan-2-yl)phosphonic acid
  参考文献：
  名称：

  Serdyukova,A.V. et al., Journal of General Chemistry of the USSR, 1978, vol. 48, p. 472 - 474

  摘要：

  DOI：

文献信息

• Studies on Organophosphorus Compounds 55. A New and Facile Synthetic Route to 1-Alkyl(Aryl)-2-amino-1-hydroxyalkylphosphonic Acids
  作者：Chengye Yuan、Deliang Chen

  DOI：10.1055/s-1992-26154

  日期：——

  Nucleophilic addition of dimethyl phosphite to acylamino ketones prepared conveniently by the Dakin-West reaction involving reaction of the corresponding α-amino acids and acid anhydrides, followed by subsequent hydrolysis affords 1-alkyl(aryl)-2-amino-1-hydroxyalkylphosphonic acids in satisfactory yield.

  将亚磷酸二甲酯与通过达金-韦斯特反应（涉及相应的δ-氨基酸和酸酐的反应）方便地制备的酰氨基酮进行亲核加成，然后进行水解，就能以令人满意的收率得到 1-烷基（芳基）-2-氨基-1-羟基烷基膦酸。
• US5804569A
  申请人：——

  公开号：US5804569A

  公开（公告）日：1998-09-08
• [EN] EXOCYCLIC-PHOSPHOETHANOLAMINES<br/>[FR] PHOSPHOETHANOLAMINES EXOCYCLIQUES
  申请人：CLARION PHARMACEUTICALS INC

  公开号：WO2000013690A1

  公开（公告）日：2000-03-16

  Disclosed are the use of certain cycloalkyl- and aryl-phosphoethanolamines as anti-inflammatory, anti-arrhythmic and local anesthetic agents. These therapeutically active cycloalkyl- and aryl-phosphoethanolamines are of the general Formula (I): R—O—PEA, wherein R is an unsubstituted or a substituted C5-7 cycloalkyl or an unsubstituted or substituted phenyl in which each substituent is hydrogen or an unsubstituted or substituted straight or branched C1-4 alkyl or C2-4 alkenyl, said substitution being one or more of C1-4 alkoxy, halo or cyano; and -O—PEA represents a phosphoethanolamine substituent. Also disclosed are intermediates for producing Formula (I) compounds.