{4-[2-(5-Methyl-2-naphthalen-2-yl-oxazol-4-yl)-ethoxy]-phenyl}-methanol | 141820-42-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: {4-[2-(5-Methyl-2-naphthalen-2-yl-oxazol-4-yl)-ethoxy]-phenyl}-methanol
• 英文别名: [4-[2-(5-methyl-2-naphthalen-2-yl-1,3-oxazol-4-yl)ethoxy]phenyl]methanol
• CAS: 141820-42-0
• 化学式: C₂₃H₂₁NO₃
• 分子量: 359.425
• InChiKey: REKGUPPICQTFHY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  55.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  {4-[2-(5-Methyl-2-naphthalen-2-yl-oxazol-4-yl)-ethoxy]-phenyl}-methanol 在 盐酸 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 生成 4-[2-(4-Chloromethyl-phenoxy)-ethyl]-5-methyl-2-naphthalen-2-yl-oxazole
  参考文献：
  名称：

  Benzyloxazolidine-2,4-diones as potent hypoglycemic agents

  摘要：

  A series of benzyloxazolidine-2,4-diones, containing oxazole-based side chains, were found to lower blood glucose levels in the genetically obese ob/ob mouse. Incorporation of a benzofuran structural element in these compounds provides greatly enhanced in vivo potency. The syntheses and structure-activity relationships for this series are detailed.

  DOI：

  10.1021/jm00109a003
• 作为产物：
  描述：

  4-[2-(5-Methyl-2-naphthalen-2-yl-oxazol-4-yl)-ethoxy]-benzaldehyde 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 0.5h， 生成 {4-[2-(5-Methyl-2-naphthalen-2-yl-oxazol-4-yl)-ethoxy]-phenyl}-methanol
  参考文献：
  名称：

  Benzyloxazolidine-2,4-diones as potent hypoglycemic agents

  摘要：

  A series of benzyloxazolidine-2,4-diones, containing oxazole-based side chains, were found to lower blood glucose levels in the genetically obese ob/ob mouse. Incorporation of a benzofuran structural element in these compounds provides greatly enhanced in vivo potency. The syntheses and structure-activity relationships for this series are detailed.

  DOI：

  10.1021/jm00109a003