| 1093961-20-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• CAS: 1093961-20-6
• 化学式: C₂₂H₂₆O₄
• 分子量: 354.446
• InChiKey: APQKPWAOLVAGBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  26
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1,1'-(4,6-二羟基苯)二乙酮 、 环己酮 在 吗啉 、 1,3-bis-n-butylimidazolium bromide 作用下， 反应 8.0h， 以80%的产率得到
  参考文献：
  名称：

  第一个离子液体促进的Kabbe缩合反应，可快速合成特有的双螺吡喃酮骨架

  摘要：

  通过在室温离子液体[bbim] Br中进行Kabbe缩合反应，由一锅中的4,6-二乙酰基间苯二酚首次合成了多种特有的双-螺并铬烷酮。

  DOI：

  10.1016/j.tetlet.2009.03.104

文献信息

• One-pot synthesis of novel spiro 2,3,7,8-tetrahydro-benzo[1,2-b:5,4-b′]dipyran-4,6-dione and 2,3,8,9-tetrahydro-benzo[1,2-b:4,3-b′]dipyran-4,10-dione derivatives
  作者：D. Ashok、D. Shravani

  DOI：10.1016/j.tetlet.2008.10.016

  日期：2008.12

  An efficient synthesis of novel spiro 2,3,7,8-tetrahydro-benzo[1,2-b:5,4-b']dipyran-4,6-dione and 2,3,8,9-tetrahydro-benzo[1,2-b:4,3-b']dipyran-4,10-dione derivatives in high yields under microwave irradiation is described. The reaction was also studied under conventional heating conditions. (C) 2008 Elsevier Ltd. All rights reserved.
• Microwave-Assisted Synthesis of Novel Spirochromanone–Aurone Hybrids and Their Antimicrobial Activity
  作者：N. Ramana Kishore、D. Ashok、M. Sarasija、N. Y. S. Murthy

  DOI：10.1134/s1070363218050298

  日期：2018.5

  New chromanone and aurone hybrids have been synthesized by conventional and microwave induced methods from substituted (E)-7-hydroxy-6-[3-(p-tolyl)acryloyl]spiro[chroman-2,1'-cyclohexan]-4-one with high yields. Structures of the synthesized compounds have been elucidated from IR, H-1 and C-13 NMR, and mass spectra. All newly synthesized compounds were tested in vitro for their antimicrobial activity. Methoxysubstituted spirochromanones revealed the best antimicrobial profile.