I+/--(Dimethylamino)-2-thiophenepropanol | 1179806-66-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: I+/--(Dimethylamino)-2-thiophenepropanol
• 英文别名: 1-(dimethylamino)-3-thiophen-2-ylpropan-1-ol
• CAS: 1179806-66-6
• 化学式: C₉H₁₅NOS
• 分子量: 185.29
• InChiKey: ACXWLTOPKSUETR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  51.7
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• PREPARATION OF N-METHYL-3-HYDROXY- 3-(2-THIENYL)PROPYLAMINE VIA NOVEL THIOPHENE DERIVATIVES CONTAINING CARBAMATE GROUPS AS INTERMEDIATES
  申请人：Degussa AG

  公开号：EP1476439A1

  公开（公告）日：2004-11-17
• [EN] PREPARATION OF N-METHYL-3-HYDROXY- 3-(2-THIENYL)PROPYLAMINE VIA NOVEL THIOPHENE DERIVATIVES CONTAINING CARBAMATE GROUPS AS INTERMEDIATES<br/>[FR] PREPARATION DE DERIVES DE N-METHYL-3-HYDROXY- 3-(2-THIENYL)PROPYLAMINE VIA DE NOUVEAUX DERIVES DE THIOPHENE CONTENANT DES GROUPES CARBAMATES EN TANT QU'INTERMEDIAIRES
  申请人：DEGUSSA

  公开号：WO2003070720A1

  公开（公告）日：2003-08-28

  A novel route is described for the synthesis of N-methyl-3-hydroxy-3-(2-thienyl)propylamine IV, which can be used as a starting compound for the preparation of duloxetine. N-methyl-3-hydroxy-3-(2-thienyl)propylamine is synthesized via novel thiophene derivatives containing carbamate groups, I and IIa, as intermediates.
• [EN] A PROCESS FOR PREPARATION OF (S)-(+)-N-METHYL-3(1-NAPHTHYLOXY)-3(2-THIENYL)PROPYLAMINE HYDROCHLORIDE<br/>[FR] PROCÉDÉ DE PRÉPARATION D'HYDROCHLORURE DE (S)-(+)-N-MÉTHYL-3(1-NAPHTHYLOXY)-3(2-THIENYL)PROPYLAMINE
  申请人：USV LTD

  公开号：WO2008093360A2

  公开（公告）日：2008-08-07

  [EN] The present invention provides an improved process for preparation of intermediate of Duloxetine base and hydrochloride salt thereof.
  [FR] L'invention concerne un procédé amélioré de préparation d'un intermédiaire d'une base de duloxetine et d'un sel hydrochlorure de celle-ci.