5-(3,4-dihydroxy-benzylidene)-3-phenyl-2-thioxo-thiazolidin-4-one | 129049-00-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 5-(3,4-dihydroxy-benzylidene)-3-phenyl-2-thioxo-thiazolidin-4-one
• 英文别名: 5-(3,4-Dihydroxy-benzyliden)-3-phenyl-2-thioxo-thiazolidin-4-on；(5Z)-5-(3,4-dihydroxybenzylidene)-3-phenyl-2-thioxo-1,3-thiazolidin-4-one；(5Z)-5-[(3,4-dihydroxyphenyl)methylidene]-3-phenyl-2-sulfanylidene-1,3-thiazolidin-4-one
• CAS: 129049-00-9
• 化学式: C₁₆H₁₁NO₃S₂
• 分子量: 329.4
• InChiKey: HRAFGHWKNFRMCY-ZROIWOOFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  118
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N-Phenyl-rhodanin 、 3,4-二羟基苯甲醛 在 硫酸 作用下， 生成 5-(3,4-dihydroxy-benzylidene)-3-phenyl-2-thioxo-thiazolidin-4-one
  参考文献：
  名称：

  Rosenmund; Boehm, Justus Liebigs Annalen der Chemie, 1924, vol. 437, p. 143

  摘要：

  DOI：

文献信息

• 2-thioxothiazolidin-4-one compounds and compositions as antimicrobial and antimalarial agents targeting enoyl-ACP reductase of type II fatty acid synthesis pathway and other cell growth pathways
  申请人：National Institute of Immunology

  公开号：EP1834642A2

  公开（公告）日：2007-09-19

  The current invention presents enoyl-ACP reductase, an enzyme of the type II fatty acid synthesis pathway as a target for treating human malarias and other infectious diseases. We also present in the current invention, 2-thioxothiazolidin-4-ones as antimicrobial and antimalarial agents. We provide 2-thioxothiazolidin-4-ones as antimicrobial and antimalarial agents either alone or in combination with other known antimicrobial and antimalarial agents with or without added adjuvants or diluents or carriers.

  本发明将 II 型脂肪酸合成途径中的一种酶--烯酰-ACP 还原酶作为治疗人类疟疾和其他传染性疾病的靶标。本发明还提出了作为抗菌剂和抗疟药物的 2-硫酮噻唑烷-4-酮。我们提供 2-硫酮噻唑烷-4-酮作为抗菌剂和抗疟药物，可以单独使用，也可以与其他已知的抗菌剂和抗疟药物结合使用，可以添加佐剂或稀释剂或载体，也可以不添加佐剂或稀释剂或载体。
• Prolylhydroxylase inhibitors and methods of use
  申请人：Cornell University

  公开号：EP2891649A1

  公开（公告）日：2015-07-08

  Compounds for inhibiting hypoxia inducible factor (HIF) prolyl-4-hydroxylases (PHDs) having the general formula: Methods of using these and related compounds for treating a patient having a condition that would benefit from inhibiting HIF PHD are also described herein.

  用于抑制具有通式的低氧诱导因子（HIF）脯氨酰-4-羟化酶（PHD）的化合物： 本文还描述了使用这些化合物和相关化合物治疗因抑制 HIF PHD 而患病的患者的方法。
• Andreasch, Monatshefte fur Chemie, 1917, vol. 38, p. 128
  作者：Andreasch

  DOI：——

  日期：——
• PROLYLHYDROXYLASE INHIBITORS AND METHODS OF USE
  申请人：Cornell University

  公开号：EP2536709A2

  公开（公告）日：2012-12-26
• 2-Thioxothiazolidin-4-one compounds and compositions as antimicrobial and antimalarial agents targeting enoyl-ACP reductase of type II fatty acid synthesis pathway and other cell growth pathways
  申请人：Surolia Avadhesha

  公开号：US20080051445A1

  公开（公告）日：2008-02-28

  The current invention presents enoyl-ACP reductase, an enzyme of the type II fatty acid synthesis pathway as a target for treating human malarias and other infectious diseases. We also present in the current invention, 2-thioxothiazolidin-4-ones as antimicrobial and antimalarial agents. We provide 2-thioxothiazolidin-4-ones as antimicrobial and antimalarial agents either alone or in combination with other known antimicrobial and antimalarial agents with or without added adjuvants or diluents or carriers.