N-[(2-methoxynaphthalen-1-yl)methylideneamino]-4-methylbenzamide | 316132-47-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-[(2-methoxynaphthalen-1-yl)methylideneamino]-4-methylbenzamide
• CAS: 316132-47-5
• 化学式: C₂₀H₁₈N₂O₂
• 分子量: 318.375
• InChiKey: UAEMIAMYLRWYFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  50.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-甲氧基-1-萘醛 、 对甲苯甲酰肼 以 乙醇 为溶剂， 生成 N-[(2-methoxynaphthalen-1-yl)methylideneamino]-4-methylbenzamide
  参考文献：
  名称：

  Diarylacylhydrazones: Clostridium-selective antibacterials with activity against stationary-phase cells

  摘要：

  Current antibiotics for treating Clostridium difficile infections (CDI), that is, metronidazole, vancomycin and more recently fidaxomicin, are mostly effective but treatment failure and disease relapse remain as significant clinical problems. The shortcomings of these agents are attributed to their low selectivity for C. difficile over normal gut microflora and their ineffectiveness against C. difficile spores. This Letter reports that certain diarylacylhydrazones identified during a high-throughput screening/counter-screening campaign show selective activity against two Clostridium species (C. difficile and Clostridium perfringens) over common gut commensals. Representative examples are shown to possess activity similar to vancomycin against clinical C. difficile strains and to kill stationary-phase C. difficile cells, which are responsible for spore production. Structure-activity relationships with additional synthesised analogues suggested a protonophoric mechanism may play a role in the observed activity/selectivity and this was supported by the well-known protonophore carbonyl cyanide m-chlorophenyl hydrazone (CCCP) showing selective anti-Clostridium effects and activity similar to diarylacylhydrazones against stationary-phase C. difficile cells. Two diarylacylhydrazones were shown to be non-toxic towards human FaDu and Hep G2 cells indicating that further studies with the class are warranted towards new drugs for CDI. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.12.015

文献信息

• Diarylacylhydrazones: Clostridium-selective antibacterials with activity against stationary-phase cells
  作者：Chao Chen、Naveen K. Dolla、Gabriele Casadei、John B. Bremner、Kim Lewis、Michael J. Kelso

  DOI：10.1016/j.bmcl.2013.12.015

  日期：2014.1

  Current antibiotics for treating Clostridium difficile infections (CDI), that is, metronidazole, vancomycin and more recently fidaxomicin, are mostly effective but treatment failure and disease relapse remain as significant clinical problems. The shortcomings of these agents are attributed to their low selectivity for C. difficile over normal gut microflora and their ineffectiveness against C. difficile spores. This Letter reports that certain diarylacylhydrazones identified during a high-throughput screening/counter-screening campaign show selective activity against two Clostridium species (C. difficile and Clostridium perfringens) over common gut commensals. Representative examples are shown to possess activity similar to vancomycin against clinical C. difficile strains and to kill stationary-phase C. difficile cells, which are responsible for spore production. Structure-activity relationships with additional synthesised analogues suggested a protonophoric mechanism may play a role in the observed activity/selectivity and this was supported by the well-known protonophore carbonyl cyanide m-chlorophenyl hydrazone (CCCP) showing selective anti-Clostridium effects and activity similar to diarylacylhydrazones against stationary-phase C. difficile cells. Two diarylacylhydrazones were shown to be non-toxic towards human FaDu and Hep G2 cells indicating that further studies with the class are warranted towards new drugs for CDI. (C) 2013 Elsevier Ltd. All rights reserved.