1,6-hexamethylene bis(ethylcarbodiimide) | 134736-12-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1,6-hexamethylene bis(ethylcarbodiimide)
• CAS: 134736-12-2
• 化学式: C₁₂H₂₂N₄
• 分子量: 222.333
• InChiKey: IYFWKMMMFIDAQJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  16
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  49.4
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Crosslinked hyaluronic acid compositions for tissue augmentation
  申请人：Sadozai K. Khalid

  公开号：US20050136122A1

  公开（公告）日：2005-06-23

  A hyaluronic acid (HA) composition includes crosslinked, water-insoluble, hydrated HA gel particles. The HA includes crosslinks represented by the following structural formula: HA—U—R 2 —U—HA The variables are defined herein. A method of augmenting tissue in a subject includes inserting a needle into a subject at a location in the subject that is in need of tissue augmentation, wherein the needle is coupled to a syringe loaded with the HA composition, and applying force to the syringe, to deliver the HA composition into the subject. A method of preparing the HA composition, includes forming water-insoluble, dehydrated crosslinked HA particles, separating the water-insoluble, dehydrated particles by average diameter, selecting a subset of particles by average diameter, and hydrating the subset of dehydrated particles with a physiologically compatible aqueous solution. Another method of preparing the crosslinked HA composition includes crosslinking a precursor of the crosslinked HA with a biscarbodiimide in the presence of a pH buffer and dehydrating the crosslinked HA. Also included is a method of augmenting tissue in a subject that is in need of tissue augmentation. A method of stabilizing crosslinked HA includes hydrating water-insoluble, dehydrated crosslinked HA with a physiologically compatible aqueous solution that includes a local anesthetic, wherein the value of storage modulus G′ for the stabilized composition is at least about 110% of the value of G′ for a non-stabilized composition,. Also included is the stabilized HA composition.

  一种透明质酸（HA）组合物包括交联的、不溶于水的、水合的HA凝胶颗粒。HA包括由以下结构式表示的交联：HA—U—R2—U—HA。变量在此定义。一种在受试者中增强组织的方法包括将针插入受试者体内需要组织增强的位置，其中针连接到装有HA组合物的注射器，并施加力量到注射器，将HA组合物注入受试者体内。一种制备HA组合物的方法包括形成不溶于水的、脱水的交联HA颗粒，通过平均直径分离不溶于水的、脱水的颗粒，通过平均直径选择颗粒的子集，并用生理兼容的水溶液使脱水的颗粒子集水化。另一种制备交联HA组合物的方法包括在pH缓冲剂存在下用双异氰酸酯交联交联HA的前体，并脱水交联HA。还包括一种在需要组织增强的受试者中增强组织的方法。一种稳定交联HA的方法包括用含有局部麻醉剂的生理兼容水溶液水化不溶于水的、脱水的交联HA，其中稳定组合物的存储模量G′的值至少为非稳定组合物G′值的约110%。还包括稳定的HA组合物。
• BIODEGRADABLE COMPOSITION COMPRISING POLYMERS OF NATURAL ORIGIN AND ALIPHATIC-AROMATIC COPOLYESTERS
  申请人：Bastioli Catia

  公开号：US20120316257A1

  公开（公告）日：2012-12-13

  The present invention relates to a biodegradable composition comprising at least one polymer of natural origin and at least one aliphatic-aromatic copolyester obtained starting from mixtures comprising aliphatic diols, polyfunctional aromatic acids, and at least two aliphatic dicarboxylic acids, at least one of which is long chain. Said composition combines improved biodegradability, excellent mechanical properties, a high level of industrial processability, limited environmental impact as well as stability of physical properties under the influence of environmental factors.

  本发明涉及一种可生物降解的组合物，包括至少一种天然来源的聚合物和至少一种由混合物制得的脂肪族芳香共聚酯，该混合物包括脂肪二醇、多官能团芳香酸和至少两种脂肪族二羧酸，其中至少一种是长链的。该组合物具有改善的生物降解性、优异的机械性能、高度的工业可加工性、有限的环境影响以及在环境因素影响下物理性能的稳定性。
• DERMAL FILLER COMPOSITIONS
  申请人：Njikang Gabriel N.

  公开号：US20160113855A1

  公开（公告）日：2016-04-28

  The present invention provides highly injectable, long-lasting hyaluronic acid-based hydrogel dermal filler compositions made with a di-amine or multiamine crosslinker in the presence of a carbodiimide coupling agent.

  本发明提供了一种高度注射性、持久的基于透明质酸的水凝胶填充剂组合物，其中在存在碳二亚胺偶联剂的情况下，采用二胺或多胺交联剂制成。
• Crosslinked Hyaluronic Acid Compositions For Tissue Augmentation
  申请人：Anika Therapeutics Inc.

  公开号：EP2656833A1

  公开（公告）日：2013-10-30

  A hyaluronic acid (HA) composition includes crosslinked, water-insoluble, hydrated HA gel particles. The HA includes crosslinks represented by the following structural formula: HA'-U-R2-U-HA'. The variables are defined herein. A method of augmenting tissue in a subject includes inserting a needle into a subject at a location in the subject that is in need of tissue augmentation, wherein the needle is coupled to a syringe loaded with the HA composition, and applying force to the syringe, to deliver the HA composition into the subject. A method of preparing the HA composition, includes forming water-insoluble, dehydrated crosslinked HA particles, separating the water-insoluble, dehydrated particles by average diameter, selecting a subset of particles by average diameter, and hydrating the subset of dehydrated particles with a physiologically compatible aqueous solution. Another method of preparing the crosslinked HA composition includes crosslinking a precursor of the crosslinked HA with a biscarbodiimide in the presence of a pH buffer and dehydrating the crosslinked HA. Also included is a method of augmenting tissue in a subject that is in need of tissue augmentation. A method of stabilizing crosslinked HA includes hydrating water-insoluble, dehydrated crosslinked HA with a physiologically compatible aqueous solution that includes a local anesthetic, wherein the value of storage modulus G' for the stabilized composition is at least about 110% of the value of G' for a non-stabilized composition. Also included is the stabilized HA composition.

  透明质酸（HA）组合物包括交联的、不溶于水的水合透明质酸凝胶颗粒。HA 包括由以下结构式表示的交联：HA'-U-R2-U-HA'。变量在此定义。一种增强受试者组织的方法，包括在受试者体内需要增强组织的位置将针头插入受试者体内，其中针头与装有HA组合物的注射器相连，并对注射器施力，将HA组合物送入受试者体内。一种制备 HA 组合物的方法包括形成不溶于水的脱水交联 HA 颗粒，按平均直径分离不溶于水的脱水颗粒，按平均直径选择颗粒子集，用生理上兼容的水溶液水合脱水颗粒子集。另一种制备交联 HA 组合物的方法包括在 pH 缓冲剂存在下用双碳化二亚胺交联交联 HA 的前体，并使交联 HA 脱水。还包括一种在需要增强组织的受试者体内增强组织的方法。一种稳定交联 HA 的方法包括将不溶于水的脱水交联 HA 与包括局麻药的生理相容水溶液水合，其中稳定化组合物的储存模量 G' 值至少是非稳定化组合物 G' 值的约 110%。还包括稳定的 HA 组合物。
• IN SITU CROSS-LINKABLE POLYSACCHARIDE COMPOSITIONS AND USES THEREOF
  申请人：Merz Pharma GmbH & Co. KGaA

  公开号：EP3156044A1

  公开（公告）日：2017-04-19

  The present invention relates to a sterile in situ cross-linkable polysaccharide compositions for augmenting, filling or replacing soft tissues in various cosmetic and therapeutic applications. The composition comprises a first polysaccharide derivative functionalized with a nucleophilic group and a second polysaccharide derivative functionalized with an electrophilic group. Said nucleophilic and electrophilic functional groups spontaneously form in situ covalent linkages following co-injection in the body of a patient, resulting in the formation of a cross-linked hydrogel at the site of co-injection.

  本发明涉及一种无菌原位可交联多糖组合物，用于在各种美容和治疗应用中增强、填充或替换软组织。该组合物包括第一种被亲核基团官能化的多糖衍生物和第二种被亲电基团官能化的多糖衍生物。所述亲核官能团和亲电官能团在患者体内共同注射后自发形成原位共价连接，从而在共同注射部位形成交联水凝胶。