5-chloro-2-imino-1-[2-(1H-inden-3-yl)ethyl]-1,2-dihydropyridine-3-carboxamide | 1021872-32-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚和异茚
• 英文名称: 5-chloro-2-imino-1-[2-(1H-inden-3-yl)ethyl]-1,2-dihydropyridine-3-carboxamide
• 英文别名: 5-chloro-2-imino-1-[2-(3H-inden-1-yl)ethyl]pyridine-3-carboxamide
• CAS: 1021872-32-1
• 化学式: C₁₇H₁₆ClN₃O
• 分子量: 313.787
• InChiKey: KQBKIXZPKVIAMC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  70.2
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• IMINOPYRIDINE DERIVATIVE AND USE THEREOF
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP2077262A1

  公开（公告）日：2009-07-08

  Provided are an iminopyridine derivative having a selective α1D adrenergic receptor antagonistic action and useful as an agent for the prophylaxis or treatment of a lower urinary tract disease and the like, and a screening method for a compound having an α1D adrenergic receptor antagonistic action. An α1D adrenergic receptor antagonist containing a compound represented by the formula: wherein each symbol is as defined in the specification, or a salt thereof, and a method of screening for an agent having an α1D adrenergic receptor antagonistic action for the prophylaxis or treatment of a lower urinary tract disease, which includes measuring the bladder smooth muscle tension of rats with bladder outlet obstruction.

  提供了一种具有选择性α1D肾上腺素能受体拮抗作用的咪唑吡啶衍生物，可用作预防或治疗下尿路疾病等药物，以及一种筛选具有α1D肾上腺素能受体拮抗作用的化合物的方法。该α1D肾上腺素能受体拮抗剂包含由下式表示的化合物或其盐：其中，每个符号如规范中所定义。该方法包括测量具有膀胱出口梗阻的大鼠膀胱平滑肌张力的药物，用于预防或治疗下尿路疾病的α1D肾上腺素能受体拮抗剂的筛选方法。
• Iminopyridine Derivative and Use Thereof
  申请人：Yoshida Masato

  公开号：US20100016315A1

  公开（公告）日：2010-01-21

  Provided are an iminopyridine derivative having a selective α 1D adrenergic receptor antagonistic action and useful as an agent for the prophylaxis or treatment of a lower urinary tract disease and the like, and a screening method for a compound having an α 1D adrenergic receptor antagonistic action. An α 1D adrenergic receptor antagonist containing a compound represented by the formula: wherein each symbol is as defined in the specification, or a salt thereof, and a method of screening for an agent having an α 1D adrenergic receptor antagonistic action for the prophylaxis or treatment of a lower urinary tract disease, which includes measuring the bladder smooth muscle tension of rats with bladder outlet obstruction.

  提供了一种具有选择性α1D肾上腺素受体拮抗作用的咪唑吡啶衍生物，可用作预防或治疗下尿路疾病等药物，以及一种筛选具有α1D肾上腺素受体拮抗作用的化合物的方法。一种含有以下式子所表示的化合物或其盐的α1D肾上腺素受体拮抗剂：其中每个符号如规范中所定义，以及一种筛选用于预防或治疗下尿路疾病的具有α1D肾上腺素受体拮抗作用的药物的方法，该方法包括测量具有膀胱出口梗阻的大鼠膀胱平滑肌张力。
• Iminopyridine derivative and use thereof
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP2535330A2

  公开（公告）日：2012-12-19

  A screening method for an agent having an α1D adrenergic receptor antagonistic action for the prophylaxis or treatment of a lower urinary tract disease, which comprises measuring the tension of the bladder smooth muscle of a bladder outlet obstruction rat.

  一种具有α1D肾上腺素能受体拮抗作用的预防或治疗下尿路疾病药物的筛选方法，包括测量膀胱出口梗阻大鼠膀胱平滑肌的张力。
• US8470859B2
  申请人：——

  公开号：US8470859B2

  公开（公告）日：2013-06-25