11-(5-chloro-2-thienyl)-2-fluorodibenzo[b,f][1,4]thiazepine-8-carboxylic acid butyl amide | 1019853-48-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并硫氮卓类
• 英文名称: 11-(5-chloro-2-thienyl)-2-fluorodibenzo[b,f][1,4]thiazepine-8-carboxylic acid butyl amide
• 英文别名: N-butyl-6-(5-chlorothiophen-2-yl)-8-fluorobenzo[b][1,4]benzothiazepine-3-carboxamide
• CAS: 1019853-48-5
• 化学式: C₂₂H₁₈ClFN₂OS₂
• 分子量: 444.981
• InChiKey: ILGJDJQCPVAJRW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  95
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• CB-1 MODULATING COMPOUNDS AND THEIR USE
  申请人：Olsson Roger

  公开号：US20080090805A1

  公开（公告）日：2008-04-17

  Disclosed herein is a compound of Formula (I). Also disclosed herein is a method of modulating the activity of a cannabinoid receptor using a compound of Formula (I). Furthermore, disclosed herein is a method of treating a disease or condition that would be alleviated, improved or prevented by administration of a compound that modulates a cannabinoid receptor comprising identifying a subject in need thereof and administering to said subject a therapeutically effective amount of a compound of Formula (I). Also disclosed herein are pharmaceutical compositions comprising a compound of Formula (I).

  本文披露了一种化合物的结构式(I)。同时也披露了使用结构式(I)的化合物调节大麻素受体活性的方法。此外，还披露了一种治疗疾病或症状的方法，该疾病或症状可以通过给予调节大麻素受体的化合物得到缓解、改善或预防，包括确定需要该方法的受试者，并向该受试者施用结构式(I)的化合物的治疗有效量。本文还披露了包含结构式(I)的药物组合物。
• METHODS FOR SYNTHESIS OF DICARBAMATE COMPOUNDS AND INTERMEDIATES IN THE FORMATION THEREOF
  申请人：MedPointe Healthcare Inc.

  公开号：EP1888570A2

  公开（公告）日：2008-02-20
• [EN] METHODS FOR SYNTHESIS OF DICARBAMATE COMPOUNDS AND INTERMEDIATES IN THE FORMATION THEREOF<br/>[FR] PROCEDES DE SYNTHESE DE COMPOSES DE DICARBAMATE ET DE PRODUITS INTERMEDIAIRES DANS LA FORMATION DE CES DERNIERS
  申请人：MEDPOINTE HEALTHCARE INC

  公开号：WO2006116007A2

  公开（公告）日：2006-11-02

  [EN] Disclosed is a method of making 2-substituted-2-halo-1,3-propanediols via reduction of corresponding malonate compounds. Also disclosed is a method of making 2-substituted-2-halo-1,3-dicarbamate compounds (such as halo derivatives of felbamate, including fluorofelbamate) via reduction of malonate compounds, followed by carbamoylation. Reduction of the malonate compounds is carried out using an electrophilic hydride reagent.
  [FR] L'invention concerne un procédé de production de 2-halo-1,3-propanediols 2-substitués par réduction de composés de malonate correspondants. Cette invention concerne également un procédé de production de composés de 2-halo-1,3-dicarbamate 2-substitué (tels que des dérivés halo de felbamate, y compris le fluorofelbamate) par réduction de composés de malonate, puis par carbamoylation. La réduction de composés de malonate est effectuée au moyen d'un hydrure réactif électrophile.