| 1450904-45-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• CAS: 1450904-45-6
• 化学式: C₆₃H₆₈N₄O₁₁Si
• 分子量: 1085.34
• InChiKey: WNZBEYBZLKYFMV-ZJLCFRETSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.41
• 重原子数：
  79.0
• 可旋转键数：
  22.0
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  185.77
• 氢给体数：
  3.0
• 氢受体数：
  13.0

反应信息

• 作为反应物：
  描述：

  叔丁基二甲硅基三氟甲磺酸酯 、 在 lutidine 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以71%的产率得到(9H-fluoren-9-yl)methyl 4-(4-((((2R,3R,4R,5R)-2-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl)oxy)diisopropylsilyl)benzamido)butanoate
  参考文献：
  名称：

  Chemical Synthesis of U1 snRNA Derivatives

  摘要：

  U1 snRNA is an interesting biological tool for splicing correction and regulation of gene expression. However, U1 snRNA has never been chemically synthesized. In this study, the first chemical synthesis of U1snRNA and its analogues was carried out. Moreover, it was found that the binding affinity of the modified U1 snRNA with an ethylene glycol linkage to snurportin 1 (nuclear import adaptor) was as high as that of the unmodified RNA.

  DOI：

  10.1021/ol401917r
• 作为产物：
  描述：

  3',5'-O-(Di-tert-butylsilanediyl)cytidine 在 吡啶 、 咪唑 、 1,3-二氯-5,5-二甲基海因 、 氟化氢吡啶 作用下， 以 四氢呋喃 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 51.67h， 生成
  参考文献：
  名称：

  Chemical Synthesis of U1 snRNA Derivatives

  摘要：

  U1 snRNA is an interesting biological tool for splicing correction and regulation of gene expression. However, U1 snRNA has never been chemically synthesized. In this study, the first chemical synthesis of U1snRNA and its analogues was carried out. Moreover, it was found that the binding affinity of the modified U1 snRNA with an ethylene glycol linkage to snurportin 1 (nuclear import adaptor) was as high as that of the unmodified RNA.

  DOI：

  10.1021/ol401917r