tert-butyl 4-{3-(2-methylbenzothiazol-5-yloxy)-2-[(methylsulfonyl)amino]propyll}piperazinecarboxylate | 1057000-54-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: tert-butyl 4-{3-(2-methylbenzothiazol-5-yloxy)-2-[(methylsulfonyl)amino]propyll}piperazinecarboxylate
• 英文别名: Tert-butyl 4-[2-(methanesulfonamido)-3-[(2-methyl-1,3-benzothiazol-5-yl)oxy]propyl]piperazine-1-carboxylate
• CAS: 1057000-54-0
• 化学式: C₂₁H₃₂N₄O₅S₂
• 分子量: 484.641
• InChiKey: MYWFRSZYBPKBCZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  138
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• Substituted heterocyclic compounds
  申请人：Zablocki Jeff

  公开号：US20060052605A1

  公开（公告）日：2006-03-09

  Disclosed are novel piperazine derivatives, useful for the treatment of various disease states, in particular diseases such as atrial and ventricular arrhythmias, diabetes, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction.

  本发明涉及一种新型哌嗪衍生物，可用于治疗各种疾病状态，特别是如心房和心室心律失常、糖尿病、间歇性跛行、普林兹梅塔尔（变异型）心绞痛、稳定和不稳定性心绞痛、运动诱发性心绞痛、充血性心力衰竭和心肌梗死等疾病。
• Substituted Heterocyclic Compounds
  申请人：Zablocki Jeff

  公开号：US20080070927A1

  公开（公告）日：2008-03-20

  Disclosed are novel piperazine and piperazine derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, diabetes, intermitten claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction.

  本发明涉及新型哌嗪和哌嗪衍生物，可用于治疗各种疾病状态，特别是心血管疾病，如心房和心室心律失常、糖尿病、间歇性跛行、普林兹梅特尔（变异型）心绞痛、稳定和不稳定型心绞痛、运动诱发性心绞痛、充血性心力衰竭和心肌梗死。
• SUBSTITUTED PIPERAZINE COMPOUNDS AND THEIR USE AS FATTY ACID OXIDATION INHIBITORS
  申请人：CV THERAPEUTICS, INC.

  公开号：EP1789407A2

  公开（公告）日：2007-05-30
• US7271169B2
  申请人：——

  公开号：US7271169B2

  公开（公告）日：2007-09-18
• US7601721B2
  申请人：——

  公开号：US7601721B2

  公开（公告）日：2009-10-13