6-bromo-2-ethyl-3-(4-methoxybenzo[d]thiazol-2-yl)quinazolin-4(3H)-one | 1382409-11-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 6-bromo-2-ethyl-3-(4-methoxybenzo[d]thiazol-2-yl)quinazolin-4(3H)-one
• 英文别名: 6-Bromo-2-ethyl-3-(4-methoxy-1,3-benzothiazol-2-yl)quinazolin-4-one
• CAS: 1382409-11-1
• 化学式: C₁₈H₁₄BrN₃O₂S
• 分子量: 416.298
• InChiKey: DVHVFJLTYIZULH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  83
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-氨基-4-甲氧基苯并噻唑 、 6-bromo-2-ethyl-4H-benzo[d][1,3]oxazin-4-one 在 吡啶 作用下， 反应 24.0h， 以69.21%的产率得到6-bromo-2-ethyl-3-(4-methoxybenzo[d]thiazol-2-yl)quinazolin-4(3H)-one
  参考文献：
  名称：

  Quinazolino–benzothiazoles: Fused pharmacophores as anticonvulsant agents

  摘要：

  A series of 6-bromo-2-ethyl-3-(substitutedbenzo[d]thiazol-2-yl)quinazolin-4(3H)-one 3 (a-j) were synthesized using appropriate synthetic route and evaluated experimentally by the Maximal Electro Shock (MES) and the PTZ-induced seizure methods. Among the tested compounds, 3-(benzo[d]thiazol-2-yl)-6-bromo-2-ethylquinazolin-4(3H)-one (3a) has shown significant activity against tonic seizure by the MES model and 6-bromo-2-ethyl-3-(6-methoxybenzo[d]thiazol-2-yl)quinazolin-4(3H)-one (3h) against clonic seizure by PTZ-induced seizure model. Not one of the selected compounds demonstrated any sign of neurotoxicity and hepatotoxicity. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.03.045

文献信息

• Quinazolino–benzothiazoles: Fused pharmacophores as anticonvulsant agents
  作者：Vinod G. Ugale、Harun M. Patel、Sudhir.G. Wadodkar、Sanjay B. Bari、Atul A. Shirkhedkar、Sanjay J. Surana

  DOI：10.1016/j.ejmech.2012.03.045

  日期：2012.7

  A series of 6-bromo-2-ethyl-3-(substitutedbenzo[d]thiazol-2-yl)quinazolin-4(3H)-one 3 (a-j) were synthesized using appropriate synthetic route and evaluated experimentally by the Maximal Electro Shock (MES) and the PTZ-induced seizure methods. Among the tested compounds, 3-(benzo[d]thiazol-2-yl)-6-bromo-2-ethylquinazolin-4(3H)-one (3a) has shown significant activity against tonic seizure by the MES model and 6-bromo-2-ethyl-3-(6-methoxybenzo[d]thiazol-2-yl)quinazolin-4(3H)-one (3h) against clonic seizure by PTZ-induced seizure model. Not one of the selected compounds demonstrated any sign of neurotoxicity and hepatotoxicity. (C) 2012 Elsevier Masson SAS. All rights reserved.