1-(4-chloro-pyridin-2-yl)-piperazine hydrochloride | 1255099-59-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-(4-chloro-pyridin-2-yl)-piperazine hydrochloride
• 英文别名: 1-(4-chloropyridin-2-yl)piperazine;hydrochloride
• CAS: 1255099-59-2
• 化学式: C₉H₁₂ClN₃*ClH
• 分子量: 234.128
• InChiKey: JZYBISHNZPRUFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.57
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  28.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(4-chloro-pyridin-2-yl)-piperazine hydrochloride 在 caesium carbonate 、 三乙胺 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 9.0h， 生成 2-[(2-{[4-(4-chloropyridin-2-yl)piperazin-1-yl]dioxo-λ6-sulfanyl}ethyl)oxy]ethan-1-ol
  参考文献：
  名称：

  PROTEOLYSIS-TARGETING CHIMERA (PROTAC) COMPOUNDS AND USES THEREOF FIELD

  摘要：

  The present disclosure relates generally to PROTAC (proteolysis-targeting chimera) compounds, pharmaceutical compositions comprising such compounds, and methods of treating various diseases and conditions with such compounds.

  公开号：

  WO2024165050A1
• 作为产物：
  描述：

  2-氟-4-氯吡啶 在 盐酸 、 N,N-二异丙基乙胺 作用下， 以 二甲基亚砜 为溶剂， 反应 11.0h， 生成 1-(4-chloro-pyridin-2-yl)-piperazine hydrochloride
  参考文献：
  名称：

  PROTEOLYSIS-TARGETING CHIMERA (PROTAC) COMPOUNDS AND USES THEREOF FIELD

  摘要：

  The present disclosure relates generally to PROTAC (proteolysis-targeting chimera) compounds, pharmaceutical compositions comprising such compounds, and methods of treating various diseases and conditions with such compounds.

  公开号：

  WO2024165050A1

文献信息

• Kinase Inhibitors
  申请人：Bastian Jolie Anne

  公开号：US20080269244A1

  公开（公告）日：2008-10-30

  The present invention provides kinase inhibitors of Formula (I). Wherein R 1 , R 2 , X and Z are as described herein, or a pharmaceutically acceptable salt thereof.

  本发明提供了式（I）的激酶抑制剂。其中R1、R2、X和Z如此处所述，或其药学上可接受的盐。
• Kinase inhibitors
  申请人：Eli Lilly and Company

  公开号：US07652015B2

  公开（公告）日：2010-01-26

  The present invention provides kinase inhibitors of Formula (I). Wherein R1, R2, X and Z are as described herein, or a pharmaceutically acceptable salt thereof.

  本发明提供了式（I）的激酶抑制剂。其中R1，R2，X和Z如本文所述，或其药学上可接受的盐。
• The discovery of potent antagonists of NPBWR1 (GPR7)
  作者：F. Anthony Romero、Nicholas B. Hastings、Remond Moningka、Zhiqiang Guo、Ming Wang、Jerry Di Salvo、Ying Lei、Dorina Trusca、Qiaolin Deng、Vincent Tong、Jenna L. Terebetski、Richard G. Ball、Feroze Ujjainwalla

  DOI：10.1016/j.bmcl.2011.11.126

  日期：2012.1

  The synthesis and evaluation of small molecule antagonists of the G protein-coupled receptor NPBWR1 (GPR7) are reported for the first time. [4-(5-Chloropyridin-2-yl)piperazin-1-yl][(1S,2S,4R)-4-[(1R)-1-(4-methoxyphenyl)ethyl]amino}-2-(thiophen-3-yl)cyclohexyl]methanone (1) emerged as a hit from a high-throughput screen. Examination of substituents that focused on replacing the 5-chloropyridine and 4-methoxybenzylamino groups of 1 led to the identification of compounds that exhibited subnanomolar potencies as low as 660 pM (9k) in the functional assay and 200 pM in the binding assay (91). (C) 2011 Elsevier Ltd. All rights reserved.
• WO2007/53394
  申请人：——

  公开号：——

  公开（公告）日：——
• KINASE INHIBITORS
  申请人：ELI LILLY AND COMPANY

  公开号：EP1943243A1

  公开（公告）日：2008-07-16