J9Bxl4PC5V | 23775-92-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: J9Bxl4PC5V
• 英文别名: [(8R,9S,10R,13S,14S,17R)-6-[(dimethylamino)methyl]-3-ethoxy-17-(2-fluoroacetyl)-10,13-dimethyl-1,2,7,8,9,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] acetate
• CAS: 23775-92-0
• 化学式: C₂₈H₄₂FNO₄
• 分子量: 475.6
• InChiKey: ZPVGJKVIJYUOCI-ORZTVLAMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• PHARMACEUTICAL COMPOSITIONS
  申请人：Charleston Laboratories, Inc.

  公开号：EP3129028A1

  公开（公告）日：2017-02-15
• [EN] PHARMACEUTICAL COMPOSITIONS<br/>[FR] COMPOSITIONS PHARMACEUTIQUES
  申请人：CHARLESTON LAB INC

  公开号：WO2015157738A1

  公开（公告）日：2015-10-15

  Provided herein are methods and compositions for effective pain treatment, which also reduce or eliminate adverse effects.
• [EN] TREATING PAIN USING A COMPOSITION COMPRISING AN OPIOID AND AN ANTIEMETIC<br/>[FR] TRAITEMENT DE LA DOULEUR À L'AIDE D'UNE COMPOSITION COMPRENANT UN OPIOÏDE ET UN ANTIÉMÉTIQUE
  申请人：CHARLESTON LABORATORIES INC

  公开号：WO2017066488A1

  公开（公告）日：2017-04-20

  Provided herein are methods and compositions for effective treatment or prevention of pain, which also reduce or eliminate adverse effects associated with an opioid analgesic. In addition, provided herein are methods and compositions for treatment or prevention of pain, and for reducing or preventing retching in a subject. Also provided herein are methods and compositions for treatment or prevention of pain, and for reducing or preventing sleep disturbances. Also provided herein are methods and compositions for treatment or prevention of pain, and for reducing or preventing a sensory or affective quality associated with the pain, such as agonizing pain, in a subject. Compositions described herein may include an opioid analgesic and an antiemetic. Compositions described herein may further include a non-opioid analgesic.