Naphthalene,1,1,2,2-tetrafluoro-1,2-dihydro-6-(trans-4-propylcyclohexyl)- | 319906-32-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: Naphthalene,1,1,2,2-tetrafluoro-1,2-dihydro-6-(trans-4-propylcyclohexyl)-
• 英文别名: 1,1,2,2-tetrafluoro-6-(trans-4-propylcyclohexyl)-1,2-dihydronaphthalene
• CAS: 319906-32-6
• 化学式: C19H22F4
• InChiKey: JMMWLWZXTQWMKQ-HDJSIYSDSA-N

物化性质

• 沸点：
  347.4±42.0 °C(Predicted)
• 密度：
  1.16±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.51
• 重原子数：
  23.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  0.0
• 氢给体数：
  0.0
• 氢受体数：
  0.0

反应信息

• 作为反应物：
  描述：

  Naphthalene,1,1,2,2-tetrafluoro-1,2-dihydro-6-(trans-4-propylcyclohexyl)- 在 palladium on activated charcoal 氢气 作用下， 生成 Naphthalene, 1,2-difluoro-6-(trans-4-propylcyclohexyl)-
  参考文献：
  名称：

  Design, Synthesis and Physical Properties of New Liquid Crystal Materials for Active Matrix LCD (2)

  摘要：

  Novel 1-fluoro- and 1,2-difluoronaphthalene derivatives were designed for active matrix LCD and were prepared through the regioselective fluorination of 6-substituted 2-naphthols. These compounds exhibited high nematic-isotropic transition temperatures with very large dielectric anisotropy and large birefringences. These results are useful for design of new liquid crystal mixtures for TFT-displays.

  DOI：

  10.1080/10587250108025059
• 作为产物：
  描述：

  6-(trans-4-Propylcyclohexyl)-2-naphthol 在 二乙胺基三氟化硫 、 Selectfluor 作用下， 以 乙腈 为溶剂， 生成 Naphthalene,1,1,2,2-tetrafluoro-1,2-dihydro-6-(trans-4-propylcyclohexyl)-
  参考文献：
  名称：

  Design, Synthesis and Physical Properties of New Liquid Crystal Materials for Active Matrix LCD (2)

  摘要：

  Novel 1-fluoro- and 1,2-difluoronaphthalene derivatives were designed for active matrix LCD and were prepared through the regioselective fluorination of 6-substituted 2-naphthols. These compounds exhibited high nematic-isotropic transition temperatures with very large dielectric anisotropy and large birefringences. These results are useful for design of new liquid crystal mixtures for TFT-displays.

  DOI：

  10.1080/10587250108025059

文献信息

• Synthesis of vicinal difluoro aromatics and intermediates thereof
  申请人：Klauck-Jacobs Axel

  公开号：US06894200B2

  公开（公告）日：2005-05-17

  A method of preparing vicinal difluoro aromatic compounds in high yield from hydroxy aromatic compounds using various bases and a method of preparing intermediates thereof. A method for making a vicinal difluoro halogenated aromatic compound including providing a tetrafluoro derivative of a halogen substituted aromatic compound, wherein the tetrafluoro derivative has two fluorine atoms on each of two adjacent carbons and at least one additional halogen substituent; reacting the tetrafluoro derivative with a reducing agent in presence of a base for a reaction time sufficient to form the vicinal difluoro halogenated aromatic compound containing two vicinal fluorine substituents and the at least one additional halogen substituent, wherein the reducing agent is used in a reducing agent effective amount sufficient to retain the at least one additional halogen substituent.

  一种从羟基芳香化合物中使用各种碱制备高产率的邻二氟芳香化合物的方法，以及制备其中间体的方法。一种制备邻二氟卤代芳香化合物的方法，包括提供卤代芳香化合物的四氟衍生物，其中该四氟衍生物在两个相邻碳上各有两个氟原子和至少一个额外的卤素取代基；将四氟衍生物与还原剂在碱的存在下反应，反应时间足以形成含有两个邻位氟取代基和至少一个额外卤素取代基的邻二氟卤代芳香化合物，其中还原剂用于保留至少一个额外卤素取代基的有效量。
• SYNTHESIS OF VICINAL DIFLUORO AROMATICS AND INTERMEDIATES THEREOF
  申请人：——

  公开号：US20020099247A1

  公开（公告）日：2002-07-25

  A method of preparing vicinal difluoro aromatic compounds in high yield from hydroxy aromatic compounds and a method of preparing intermediates thereof. The hydroxy aromatic compound can be a mono-, bi- or tricyclic aromatic in which the rings are separate or fused. One or more of the rings can contain heteroatoms, such as oxygen, nitrogen, or sulfur, and can contain one or more substitutions, in addition to the hydroxy substitution.

  从羟基芳香化合物制备高收率的邻二氟芳香化合物的方法以及制备其中间体的方法。羟基芳香化合物可以是一个单环、双环或三环芳香化合物，其中环是分开的或融合的。一个或多个环可以含有杂原子，如氧、氮或硫，并且除了羟基取代外，还可以含有一个或多个取代基。
• US6455744B1
  申请人：——

  公开号：US6455744B1

  公开（公告）日：2002-09-24
• US6515191B2
  申请人：——

  公开号：US6515191B2

  公开（公告）日：2003-02-04
• US6706933B2
  申请人：——

  公开号：US6706933B2

  公开（公告）日：2004-03-16