3,5-Diethyl-4,N-dihydroxy-benzamidine | 944326-98-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 3,5-Diethyl-4,N-dihydroxy-benzamidine
• 英文别名: 3,5-diethyl-N',4-dihydroxybenzenecarboximidamide
• CAS: 944326-98-1
• 化学式: C₁₁H₁₆N₂O₂
• 分子量: 208.26
• InChiKey: BDOYDRJHGSZDSD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  78.8
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-isobutyl-3,5-dimethylthiophene-2-carboxylic acid 、 3,5-Diethyl-4,N-dihydroxy-benzamidine 生成 2,6-diethyl-4-[5-(4-isobutyl-3,5-dimethylthiophen-2-yl)-[1,2,4]oxadiazol-3-yl]phenol
  参考文献：
  名称：

  Thiophene derivatives as S1P1/EDG1 receptor agonists

  摘要：

  本发明涉及公式(I)的噻吩衍生物/它们的制备以及它们作为药物活性化合物的用途。所述化合物特别作为免疫抑制剂，其中：A代表*—CO—CH═CH—、*—CO—CH2CH2—、*—CO—CH2—NH—，其中星号表示与公式(I)的噻吩基团连接的键，而R1-R3如权利要求所定义。

  公开号：

  US08003800B2
• 作为产物：
  描述：

  2,6-二乙基苯胺 生成 3,5-Diethyl-4,N-dihydroxy-benzamidine
  参考文献：
  名称：

  WO2008/29306

  摘要：

  公开号：

文献信息

• AMINO-PYRIDINE DERIVATIVES AS S1P1 /EDG1 RECEPTOR AGONISTS
  申请人：Bolli Martin

  公开号：US20100087417A1

  公开（公告）日：2010-04-08

  The invention relates to novel amino-pyridine derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.

  该发明涉及新型氨基吡啶衍生物，其制备以及它们作为药用活性化合物的用途。这些化合物特别作为免疫调节剂。
• Pyridin-3-yl derivatives as immunomodulating agents
  申请人：Bolli Martin

  公开号：US20100168005A1

  公开（公告）日：2010-07-01

  The invention relates to pyridin-3-yl derivatives of Formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 ; R 6 and A are as described in the description, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.

  该发明涉及Formula (I)中的吡啶-3-基衍生物，其中R1、R2、R3、R4、R5、R6和A如描述中所述，它们的制备以及它们作为药用活性化合物的用途。这些化合物特别作为免疫调节剂。
• Pyridin-4-yl derivatives as immunomodulating agents
  申请人：Bolli Martin

  公开号：US20100063108A1

  公开（公告）日：2010-03-11

  The invention relates to pyridine derivatives of Formula (I) wherein A, R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are as described in the description, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.

  该发明涉及公式（I）中的吡啶衍生物，其中A、R1、R2、R3、R4、R5和R6如描述中所述，它们的制备以及它们作为药用活性化合物的用途。所述化合物特别作为免疫调节剂。
• Thiophene derivatives as S1P1/EDGE1 receptor agonists
  申请人：Bolli Martin

  公开号：US20100048648A1

  公开（公告）日：2010-02-25

  The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.

  这项发明涉及新型噻吩衍生物，其制备以及作为药用活性化合物的用途。所述化合物特别作为免疫调节剂。
• PHENYL DERIVATIVES AND THEIR USE AS IMMUNOMODULATORS
  申请人：Bolli Martin

  公开号：US20100087495A1

  公开（公告）日：2010-04-08

  The invention relates to phenyl derivatives of formula (I), their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.

  本发明涉及公式（I）的苯基衍生物，它们的制备以及它们作为药物活性化合物的用途。所述化合物特别作为免疫调节剂。