(S)-3-(1-aminoethyl)-isoquinolin-1(2H)-one | 1420627-44-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: (S)-3-(1-aminoethyl)-isoquinolin-1(2H)-one
• 英文别名: 3-[(1S)-1-aminoethyl]-8-chloro-2-(4-fluorophenyl)isoquinolin-1-one
• CAS: 1420627-44-6
• 化学式: C₁₇H₁₄ClFN₂O
• 分子量: 316.762
• InChiKey: HFRSOYRNTLUMQN-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• HETEROCYCLIC COMPOUNDS AND USES THEREOF
  申请人：INFINITY PHARMACEUTICALS, INC.

  公开号：US20130267521A1

  公开（公告）日：2013-10-10

  Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

  本发明描述了调节激酶活性的化合物和药物组合物，包括PI3激酶活性，以及用于治疗与激酶活性相关的疾病和状况的化合物、药物组合物和方法，包括PI3激酶活性。
• [EN] HETEROCYCLIC COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES ET LEURS UTILISATIONS
  申请人：INFINITY PHARMACEUTICALS INC

  公开号：WO2013154878A1

  公开（公告）日：2013-10-17

  Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

  本文描述了调节激酶活性，包括PI3激酶活性的化合物和制药组合物，以及与激酶活性，包括PI3激酶活性相关的疾病和病症的治疗方法、化合物和制药组合物。
• Quinazoline derivative or its salt and pharmaceutical composition comprising the same
  申请人：YUHAN CORPORATION

  公开号：US10941136B2

  公开（公告）日：2021-03-09

  The present invention provides a quinazoline derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, a pharmaceutical composition comprising the same and a use thereof. The quinazoline derivative or its pharmaceutically acceptable salt has a selective inhibitory activity against the phosphatidylinositol 3-kinase delta subunit, and therefore can be usefully applied for preventing or treating cancer, along with avoiding side effects such as lymphopenia-associated inflammatory responses.

  本发明提供了一种喹唑啉衍生物或其药学上可接受的盐、其制备工艺、包含喹唑啉衍生物或其药学上可接受的盐的药物组合物及其用途。喹唑啉衍生物或其药学上可接受的盐对磷脂酰肌醇 3- 激酶 delta 亚基具有选择性抑制活性，因此可有效地用于预防或治疗癌症，同时避免副作用，如淋巴细胞减少相关的炎症反应。
• QUINAZOLINE DERIVATIVE OR ITS SALT AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
  申请人：Yuhan Corporation

  公开号：EP3448839B1

  公开（公告）日：2022-02-09
• US8785470B2
  申请人：——

  公开号：US8785470B2

  公开（公告）日：2014-07-22