4-甲基-5-苯基-2-哌嗪酮 | 153787-48-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: 4-甲基-5-苯基-2-哌嗪酮
• 英文名称: 4-methyl-5-phenylpiperazin-2-one
• CAS: 153787-48-5
• 化学式: C₁₁H₁₄N₂O
• 分子量: 190.245
• InChiKey: HULOHTABKUUEAL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(5-chloro-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)morpholine 、 4-甲基-5-苯基-2-哌嗪酮 在 tris-(dibenzylideneacetone)dipalladium(0) 、 4,5-双二苯基膦-9,9-二甲基氧杂蒽 作用下， 以 二甲基亚砜 为溶剂， 以0.6 mg的产率得到4-methyl-1-(7-morpholino-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-5-phenylpiperazin-2-one
  参考文献：
  名称：

  [EN] COMPOUNDS AND COMPOSITIONS THAT INHIBIT PIKFYVE
  [FR] COMPOSÉS ET COMPOSITIONS QUI INHIBENT PIKFYVE

  摘要：

  Pyrazolo[1,5-a]pyrimidines are disclosed. These compounds may be useful in the treatment of neurological disorder, including frontotemporal dementia, chronic traumatic encephalopathy, Alzheimer's disease, limbic-predominant age-related TDP-43 encephalopathy, or frontotemporal lobar degeneration. Further, the invention features a method of inhibiting toxicity in a cell related to a protein TDP-43 or C9orf72. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

  公开号：

  WO2023107557A1
• 作为产物：
  描述：

  ethyl 2-(2-azido-1-phenylethylamino)acetate 在 potassium carbonate 、 三苯基膦 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 反应 8.0h， 生成 4-甲基-5-苯基-2-哌嗪酮
  参考文献：
  名称：

  [EN] COMPOUNDS AND COMPOSITIONS THAT INHIBIT PIKFYVE
  [FR] COMPOSÉS ET COMPOSITIONS QUI INHIBENT PIKFYVE

  摘要：

  Pyrazolo[1,5-a]pyrimidines are disclosed. These compounds may be useful in the treatment of neurological disorder, including frontotemporal dementia, chronic traumatic encephalopathy, Alzheimer's disease, limbic-predominant age-related TDP-43 encephalopathy, or frontotemporal lobar degeneration. Further, the invention features a method of inhibiting toxicity in a cell related to a protein TDP-43 or C9orf72. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

  公开号：

  WO2023107557A1

文献信息

• [EN] COMPOUNDS AND COMPOSITIONS THAT INHIBIT PIKFYVE<br/>[FR] COMPOSÉS ET COMPOSITIONS QUI INHIBENT PIKFYVE
  申请人：[en]KINETA, INC.

  公开号：WO2023107557A1

  公开（公告）日：2023-06-15

  Pyrazolo[1,5-a]pyrimidines are disclosed. These compounds may be useful in the treatment of neurological disorder, including frontotemporal dementia, chronic traumatic encephalopathy, Alzheimer's disease, limbic-predominant age-related TDP-43 encephalopathy, or frontotemporal lobar degeneration. Further, the invention features a method of inhibiting toxicity in a cell related to a protein TDP-43 or C9orf72. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.