4-((7-methoxy-2,3-dihydrobenzo[f][1,4]thiazepin-4(5H)-yl)methyl)benzonitrile | 1467605-87-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并硫氮卓类
• 英文名称: 4-((7-methoxy-2,3-dihydrobenzo[f][1,4]thiazepin-4(5H)-yl)methyl)benzonitrile
• 英文别名: 4-[(7-methoxy-3,5-dihydro-2H-1,4-benzothiazepin-4-yl)methyl]benzonitrile
• CAS: 1467605-87-3
• 化学式: C₁₈H₁₈N₂OS
• 分子量: 310.42
• InChiKey: WONWINAZRQOULX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  61.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• AGENTS FOR TREATING DISORDERS INVOLVING MODULATION OF RYANODINE RECEPTORS
  申请人：LES LABORATOIRES SERVIER

  公开号：US20130281512A1

  公开（公告）日：2013-10-24

  The present invention relates to 1,4-benzothiazepine derivatives and their use to treat conditions, disorders and diseases associated with ryanodine receptors (RyRs) that regulate calcium channel functioning in cells. The invention also discloses pharmaceutical compositions comprising the compounds and uses thereof to treat diseases and conditions associated with RyRs, in particular cardiac, musculoskeletal and central nervous system (CNS) disorders.

  本发明涉及1,4-苯并噻吩啉衍生物及其用于治疗与调节细胞内钙通道功能的利纳碱受体（RyRs）相关的病症、紊乱和疾病。该发明还披露了包含这些化合物的药物组合物，并用于治疗与RyRs相关的疾病和症状，特别是心脏、肌肉骨骼和中枢神经系统（CNS）紊乱。
• Agents for treating disorders involving modulation of ryanodine receptors
  申请人：Les Laboratoires Servier

  公开号：EP2653466A1

  公开（公告）日：2013-10-23

  The present invention relates to 1,4-benzothiazepine derivatives and their use to treat conditions, disorders and diseases associated with ryanodine receptors (RyRs) that regulate calcium channel functioning in cells. The invention also discloses pharmaceutical compositions comprising the compounds and uses thereof to treat diseases and conditions associated with RyRs, in particular cardiac, musculoskeletal and central nervous system (CNS) disorders.

  本发明涉及 1,4-苯并硫氮杂卓衍生物及其用于治疗与调节细胞中钙离子通道功能的雷诺丁受体（RyRs）有关的病症、紊乱和疾病的用途。本发明还公开了包含这些化合物的药物组合物及其用于治疗与RyRs相关的疾病和病症的用途，特别是心脏、肌肉骨骼和中枢神经系统（CNS）疾病。
• US8853198B2
  申请人：——

  公开号：US8853198B2

  公开（公告）日：2014-10-07