3-Ethoxy-1-azabicyclo[2,2,2]octane | 111596-47-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 奎宁环
• 英文名称: 3-Ethoxy-1-azabicyclo[2,2,2]octane
• 英文别名: 3-Ethoxy-1-azabicyclo[2.2.2]octane
• CAS: 111596-47-5
• 化学式: C₉H₁₇NO
• 分子量: 155.24
• InChiKey: ZWWMOLIAJVGEKZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• AZA-BICYCLOALKYL ETHERS AND THEIR USE AS ALPHA7-NACHR AGONISTS
  申请人：Novartis AG

  公开号：US20170112814A1

  公开（公告）日：2017-04-27

  The present invention relates to 1-aza-bicycloalkyl derivatives of formula I, wherein X is CH 2 or a single bond; Y is a group of formula and wherein R has the meanings as defined in the specification, which compounds are alpha 7 nicotinic acetylcholine receptor (nAChR) agonists; to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.

  本发明涉及式I的1-aza-bicycloalkyl衍生物，其中X是CH2或单键；Y是式的基团，其中R的含义如规范中所定义，这些化合物是α7尼古丁乙酰胆碱受体(nAChR)激动剂；以及它们的生产过程，它们作为药物的用途以及包含它们的药物组合物。
• Sirtuin modulating compounds
  申请人：Nunes Joseph J.

  公开号：US20090099170A1

  公开（公告）日：2009-04-16

  Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

  本文提供了新型的调节sirtuin的化合物及其使用方法。这些sirtuin调节化合物可用于延长细胞寿命，并治疗和/或预防各种疾病和紊乱，包括与衰老或压力相关的疾病或紊乱、糖尿病、肥胖症、神经退行性疾病、心血管疾病、血液凝块紊乱、炎症、癌症和/或潮红，以及需要增加线粒体活性的疾病或紊乱。此外，还提供了包含sirtuin调节化合物与另一种治疗药物组合的组合物。
• 1,7-DIAZACARBAZOLES AND METHODS OF USE
  申请人：Dyke Hazel Joan

  公开号：US20110183938A1

  公开（公告）日：2011-07-28

  The invention relates to 1,7-diazacarbazole compounds of Formula (I), (I-a) and (I-b) which are useful as kinase inhibitors, more specifically useful as checkpoint kinase 1 (chk1) inhibitors, thus useful as cancer therapeutics. The invention also relates to compositions, more specifically pharmaceutical compositions comprising these compounds and methods of using the same to treat various forms of cancer and hyperproliferative disorders, as well as methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.

  该发明涉及1,7-二氮杂咔唑化合物的公式（I）、（I-a）和（I-b），它们可用作激酶抑制剂，更具体地用作检查点激酶1（CHK1）抑制剂，因此可用作癌症治疗剂。该发明还涉及包含这些化合物的组合物，更具体地是药物组合物，以及使用它们治疗各种癌症和高增殖性疾病的方法，以及使用这些化合物进行哺乳动物细胞的体外、原位和体内诊断或治疗，或相关病理条件的方法。
• DIAZACARBAZOLES AND METHODS OF USE
  申请人：Chen Huifen

  公开号：US20110118230A1

  公开（公告）日：2011-05-19

  The invention relates to 1,7-diazacarbazole compounds of Formula (I), (I-a) and (I-b) which are useful as kinase inhibitors, more specifically useful as checkpoint kinase 1 (chk1) inhibitors, thus useful as cancer therapeutics. The invention also relates to compositions, more specifically pharmaceutical compositions comprising these compounds and methods of using the same to treat various forms of cancer and hyperproliferative disorders, as well as methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.

  本发明涉及式（I），（I-a）和（I-b）的1,7-二氮杂咔唑化合物，其作为激酶抑制剂有用，更具体地作为检查点激酶1（chk1）抑制剂有用，因此可用作癌症治疗剂。本发明还涉及包含这些化合物的组合物，更具体地是药物组合物，并使用它们治疗各种形式的癌症和增生性疾病的方法，以及使用这些化合物进行哺乳动物细胞的体外、原位和体内诊断或治疗的方法，或相关的病理条件。
• AZA-BICYLOALKYL ETHERS AND THEIR USE AS ALPHA7-NACHR AGONISTS
  申请人：Novartis AG

  公开号：US20150183794A1

  公开（公告）日：2015-07-02

  The present invention relates to 1-aza-bicycloalkyl derivatives of formula I, wherein X is CH 2 or a single bond; Y is a group of formula and wherein R has the meanings as defined in the specification, which compounds are alpha 7 nicotinic acetylcholine receptor (nAChR) agonists; to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.

  本发明涉及式I的1-aza-bicycloalkyl衍生物，其中X为CH2或单键；Y为公式的基团，其中R的含义如规范中定义的那样，这些化合物是α7尼古丁乙酰胆碱受体（nAChR）激动剂；其生产过程，它们作为药物的用途以及包含它们的药物组合物。