4-Methylaminomethyl-1-formyl-cyclohexan | 37485-19-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-Methylaminomethyl-1-formyl-cyclohexan
• 英文别名: 4-(Methylaminomethyl)cyclohexane-1-carbaldehyde
• CAS: 37485-19-1
• 化学式: C₉H₁₇NO
• 分子量: 155.24
• InChiKey: QMEJEXYXMIORSI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• GLP-1 derivatives and uses thereof
  申请人：Novo Nordisk A/S

  公开号：US10195255B2

  公开（公告）日：2019-02-05

  The invention relates to a derivative of a GLP-1 analogue, optionally C-terminally extended, which derivative comprises a first and a second protracting moiety in the form of a C20 or C22 diacid radical, a bis-amino branched linker, and a first and a second further linker each comprising an OEG-like linker element; wherein these elements are interconnected via amide bonds and attached to a Lys residue of the GLP-1 analogue. The invention also relates to intermediate products in the form of novel GLP-1 analogues incorporated in the derivatives of the invention, as well pharmaceutical compositions and medical uses of the derivatives. The derivatives have very long half-lives while maintaining a satisfactory potency, which makes them potentially suitable for once-monthly administration.

  本发明涉及一种可选择 C 端延伸的 GLP-1 类似物的衍生物，该衍生物包括以 C20 或 C22 二酸基形式存在的第一和第二延伸分子、双氨基支链连接体，以及第一和第二进一步连接体，每个连接体均包括 OEG 样连接体元件；其中这些元件通过酰胺键相互连接，并连接到 GLP-1 类似物的赖氨酸残基上。本发明还涉及掺入本发明衍生物中的新型 GLP-1 类似物形式的中间产物，以及衍生物的药物组合物和医疗用途。这些衍生物具有很长的半衰期，同时又能保持令人满意的药效，因此可能适用于每月给药一次。
• LONG-ACTING Y2 RECEPTOR AGONISTS
  申请人：Kofoed Jacob

  公开号：US20130096055A1

  公开（公告）日：2013-04-18

  The present invention relates to PYY derivatives comprising a serum albumin binding side chain, wherein said derivative has a half-life of at least 7 hours as determined by Assay (IV) described herein as well as compositions comprising said derivative and its use in therapy.