2,6-Ditert-butyl-4-[(3-pyridin-4-yloxypropylamino)methyl]phenol | 1148000-10-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2,6-Ditert-butyl-4-[(3-pyridin-4-yloxypropylamino)methyl]phenol
• CAS: 1148000-10-5
• 化学式: C₂₃H₃₄N₂O₂
• 分子量: 370.535
• InChiKey: STHSXRBOOHTVIS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  27
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  54.4
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• ARYLOXY AMINE COMPOUNDS AND THEIR USE AS SODIUM CHANNEL MODULATORS
  申请人：JARROTT Bevyn

  公开号：US20140323527A1

  公开（公告）日：2014-10-30

  The present invention relates generally to the field of therapeutic treatment and compounds having utility therefor, in particular the therapy or management of conditions associated with excessive, unwanted or undesirable sodium ion passage through cellular membranes via voltage-gated sodium channels. In one embodiment the invention is concerned with the treatment of neuropathic pain. The invention contemplates to aryloxy-substituted amines, as sodium channel blockers or modulators. In further embodiments, the invention also relates to compounds which may advantageously have dual sodium channel blocker/modulating and antioxidative (free-radical scavenging) effects. Methods for their manufacture and compositions containing the compounds are also contemplated.

  本发明涉及治疗性治疗领域和具有相关效用的化合物，特别是治疗或管理与细胞膜通过电压门控钠通道过度、不需要或不想要的钠离子通量相关的疾病。在一种实施方式中，本发明涉及神经病性疼痛的治疗。本发明考虑到芳氧基取代胺作为钠通道阻滞剂或调节剂。在进一步的实施方式中，本发明还涉及化合物，这些化合物可能具有双重钠通道阻滞/调节和抗氧化（自由基清除）效果。本发明还考虑到它们的制造方法和含有这些化合物的组合物。