O,O-dimethyl phosphorohydrazidothioate | 59895-96-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫代磷酸及其衍生物
• 英文名称: O,O-dimethyl phosphorohydrazidothioate
• 英文别名: O,O-Dimethyl-thiophosphorsaeurehydrazid；Monothiophosphorsaeure-O,O-dimethylester-hydrazid；O,O-Dimethyl-phosphorohydrazidothionat；thiophosphorohydrazidic acid O,O-dimethyl ester；hydrazidothiophosphoric acid O,O-dimethyl ester；Hydrazidothiophosphorsaeure-O,O-dimethylester；O,O'-Dimethyl-hydrazidothiophosphat；Dimethoxyphosphinothioylhydrazine
• CAS: 59895-96-4
• 化学式: C₂H₉N₂O₂PS
• 分子量: 156.145
• InChiKey: WHIMFWOOTUHRLG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  88.6
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  O,O-dimethyl phosphorohydrazidothioate 、 potassium ethyl xanthogenate 生成 N'-dimethoxythiophosphoryl-hydrazinecarbothioic acid O-ethyl ester
  参考文献：
  名称：

  研究具有杂环取代基的磷酸和硫代磷酸酯。6.沟通。3-酰基-硫代-和-二硫代-氨基甲酸烷基酯和2'-（二烷氧基-膦硫基）-羧酸酰肼及其闭环成3-酰基-5-烷氧基-和-5-烷基硫代-1,3 ，4-噻二唑-2（3 H）-ones或3-（二烷氧基膦硫基硫基）-5-取代-1,3,4-恶二唑-2（3 H）-ones †

  摘要：

  在3位上被羧酸，磺酸，磷酸，硫代磷酸或硫代膦酸的自由基酰化的硫代和二硫代氨基甲酸烷基酯，在没有任何酸结合剂的情况下，用光气自发地闭环，形成相应的3-酰基-5-烷氧基-和-5-烷硫基-1,3,4-噻二唑-2（3 H）-。类似地，可以由被硫代磷酸基团酰化的羧酸酰肼制备3-硫代磷酸化的5-取代的1,3,4-恶二唑-2（3H）-。然而，在后一种情况下，需要化学计量的吡啶以避免PN键的断裂。

  DOI：

  10.1002/hlca.19730560108
• 作为产物：
  描述：

  二甲基硫代磷酰氯 在 一水合肼 、 苯 作用下， 生成 O,O-dimethyl phosphorohydrazidothioate
  参考文献：
  名称：

  The Nucleophilicity of Phosphorohydrazidothionates

  摘要：

  DOI：

  10.1021/ja00870a020

文献信息

• Melnikow; Senkewitsch, Zhurnal Obshchei Khimii, 1955, vol. 25, p. 828,829;engl.Ausg.S.793
  作者：Melnikow、Senkewitsch

  DOI：——

  日期：——
• An efficient synthesis of O,O- Di Propyl (E)-2-[1-methyl 2-oxopropylidene]phosphorohydrazidothiolate (E) Oxime and Its Analogues: A Potential Marine Toxin
  作者：Arvind K. Gupta、D. K. Dubey、B. D. Parashar、M. P. Kaushik

  DOI：10.1080/10426500701796249

  日期：2008.7.4

  An efficient method for the synthesis of Ptychodiscus brevis toxin O,O- di n-propyl (E)-2-[1-methyl 2-oxopropylidene]phosphorohydrazidothiolate (E) oxime (TG-1) and its analogues has been developed using thermally stable and recyclable silica gel and Na2SO4 as a condensing agent and water scavenger, respectively. The compounds were evaluated against fish Rasbora daniconius by determining the LC50 and LC90 values. The results of biological evaluation showed that these compounds have high degree of toxicity.
• Nikonorov, K. V.; Ganiev, F. F.; Antokhina, L. A., Journal of general chemistry of the USSR, 1989, vol. 59, # 4.1, p. 716 - 718
  作者：Nikonorov, K. V.、Ganiev, F. F.、Antokhina, L. A.

  DOI：——

  日期：——
• Regioselective synthesis of novel 3-alkoxy (phenyl) thiophosphorylamido-2-(per-O-acetylglycosyl-1′-imino)thiazolidine-4-one derivatives from O-alkyl N4-glycosyl(thiosemicarbazido)phosphonothioates
  作者：Yu Xin Li、Hao An Wang、Xiao Ping Yang、Hai Ying Cheng、Zhi Hong Wang、Yi Ming Li、Zheng Ming Li、Su Hua Wang、Dong Wen Yan

  DOI：10.1016/j.carres.2009.03.027

  日期：2009.7

  A series of 3-alkoxy(phenyl)thiophosphorylamido-2-(per-O-acetylglycosyl-1'-imino)thiazolidine-4-one derivatives were prepared by the reaction of 1-alkoxy(phenyl)thiophosphoryl-4-(per-O-acetylglycosyl) thiosemicarbazides with ethyl bromoacetate. H-1/C-13 HMBC measurements corroborated by X-ray crystallographic results revealed the exclusive regioselectivity of these ring closures toward the N-2 position of the thiosemicarbazide moiety. The bioactivity data of 3a-k suggest that the thiazolidine-4-one ring is critical for the herbicidal and fungicidal activities. (C) 2009 Elsevier Ltd. All rights reserved.
• NIKONOROV, K. V.;GANIEV, F. F.;ANTOXINA, L. A., ZH. OBSHCH. XIMII, 59,(1989) N, S. 811-814
  作者：NIKONOROV, K. V.、GANIEV, F. F.、ANTOXINA, L. A.

  DOI：——

  日期：——