N-[2]thienyl-butyramide | 80886-68-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-[2]thienyl-butyramide
• 英文别名: N-[2]Thienyl-butyramid；N-(thien-2-yl)-butyric acid amide；N-(2-thienyl)-butyric acid amide；N-thiophen-2-ylbutanamide
• CAS: 80886-68-6
• 化学式: C₈H₁₁NOS
• 分子量: 169.247
• InChiKey: KOBIRIKKSYIDTK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  57.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof
  申请人：Sekiguchi Yoshinori

  公开号：US20050197350A1

  公开（公告）日：2005-09-08

  The present invention relates to novel compounds of the Formula (I): which act as MCH receptor antagonists. These compositions are useful in pharmaceutical compositions whose use includes prophylaxis or treatment of improving memory function, sleeping and arousal, anxiety, depression, mood disorders, seizure, obesity, diabetes, appetite and eating disorders, cardiovascular disease, hypertension, dyslipidemia, myocardial infarction, binge eating disorders including bulimia, anorexia, mental disorders including manic depression, schizophrenia, delirium, dementia, stress, cognitive disorders, attention deficit disorder, substance abuse disorders and dyskinesias including Parkinson's disease, epilepsy, and addiction.

  本发明涉及一种新的化合物，其化学式为(I)，该化合物作为MCH受体拮抗剂。这些组合物在制药组合物中的应用包括预防或治疗改善记忆功能、睡眠和觉醒、焦虑、抑郁、情绪障碍、癫痫、肥胖症、糖尿病、食欲和进食障碍、心血管疾病、高血压、血脂异常、心肌梗死、暴食症包括贪食症、厌食症、精神障碍包括躁郁症、精神分裂症、谵妄、痴呆、压力、认知障碍、注意力缺陷障碍、物质滥用障碍和运动障碍包括帕金森病、癫痫和成瘾等。
• New 5-(N-alkyl-N-acyl-amino)-thiophen-2-carboxylic acid derivatives, process for producing the same and pharmaceutical compounds containing the same
  申请人：A. Nattermann & Cie. GmbH

  公开号：EP0078860A1

  公开（公告）日：1983-05-18

  The present invention refers to new 5-(N-Alkyl-N-acylamino)-thiophen-2-carboxylic acid derivatives having the general formula I process for producing the same and pharmaceutical compounds containing the same as active ingredient.

  本发明是指具有通式 I 的新的 5-(N-烷基-N-酰氨基)-噻吩-2-羧酸衍生物，以及含有这些衍生物作为活性成分的药物化合物。
• PESTICIDAL COMPOSITIONS AND RELATED METHODS
  申请人：Dow AgroSciences LLC

  公开号：EP3071036A1

  公开（公告）日：2016-09-28
• US4349686A
  申请人：——

  公开号：US4349686A

  公开（公告）日：1982-09-14
• [EN] PESTICIDAL COMPOSITIONS AND RELATED METHODS<br/>[FR] COMPOSITIONS PESTICIDES ET PROCÉDÉS ASSOCIÉS
  申请人：DOW AGROSCIENCES LLC

  公开号：WO2015061165A1

  公开（公告）日：2015-04-30

  A pesticidal composition comprises at least one compounds selected from a compound of formula (I), or any agriculturally acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7,R8, Q, Z, L, La, and x are as described herein. A method of controlling pests comprises applying the pesticidal composition near a population of pests.