4-甲基己烷-1-胺 | 34263-68-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 4-甲基己烷-1-胺
• 英文名称: 4-Methylhexan-1-amine
• CAS: 34263-68-8
• 化学式: C₇H₁₇N
• 分子量: 115.22
• InChiKey: HZZLWSFAPDJVLT-UHFFFAOYSA-N

物化性质

• 沸点：
  80 °C(Press: 90 Torr)
• 密度：
  0.7709 g/cm3(Temp: 25 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2921199090

文献信息

• METHOD FOR PRODUCING BETA -ALKOXYPROPIONAMIDE
  申请人：Idemitsu Kosan Co., Ltd

  公开号：EP2837619A1

  公开（公告）日：2015-02-18

  A method for producing a β-alkoxypropionamide including reacting a β-alkoxypropionic acid ester represented by the following formula (1) and an amine represented by the following formula (2) in the presence of a polyol and a basic catalyst, thereby to produce a β-alkoxypropionamide represented by the following formula (3), wherein, as the polyol, a reaction residue that is generated by the reaction and contains a used polyol is used: (wherein in the formulas, R and R' are independently a C1 to C6 linear, branched or cyclic, saturated hydrocarbon group; R1 and R2 are independently a C1 to C6 linear, branched or cyclic, saturated hydrocarbon group; and R3 is H or CH3).

  生产β-烷氧基丙酰胺的方法包括在多元醇和碱性催化剂存在下，使以下式（1）所代表的β-烷氧基丙酸酯与以下式（2）所代表的胺发生反应，从而生成以下式（3）所代表的β-烷氧基丙酰胺， 其中作为多元醇，使用由反应生成并含有已使用的多元醇的反应残留物：（在公式中，R和R'分别是C1到C6的直链、支链或环状饱和碳氢基团；R1和R2分别是C1到C6的直链、支链或环状饱和碳氢基团；R3是H或CH3）。
• [EN] SPIROPYRROLIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE<br/>[FR] INHIBITEURS DE BÊTA-SÉCRÉTASE DE TYPE SPIROPYRROLIDINE POUR LE TRAITEMENT DE LA MALADIE D'ALZHEIMER
  申请人：MERCK SHARP & DOHME

  公开号：WO2010094242A1

  公开（公告）日：2010-08-26

  The present invention is directed to spiropyrrolidine compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

  本发明涉及式(I)的螺环吡咯烷化合物，它们是β-分泌酶的抑制剂，并且在治疗涉及β-分泌酶的疾病，如阿尔茨海默病中有用。该发明还涉及包含这些化合物的药物组合物，以及在治疗涉及β-分泌酶的这类疾病中使用这些化合物和组合物。
• [EN] PROCESS FOR THE PREPRATION OF 7-(4,7-DIAZASPIRO[2.5]OCTAN-7-YL)-2-(2,8-DIMETHYLIMIDAZO[1,2-B]PYRIDAZIN-6-YL)PYRIDO[1,2-A]PYRIMIDIN-4-ONE DERIVATIVES<br/>[FR] PROCÉDÉ DE PRÉPARATION DE DÉRIVÉS DE 7-(4,7-DIAZASPIRO[2.5]OCTAN-7-YL)-2-(2,8-DIMÉTHYLIMIDAZO[1,2-B]PYRIDAZIN-6-YL)PYRIDO[1,2-A]PYRIMIDIN-4-ONE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2019057740A1

  公开（公告）日：2019-03-28

  The present invention relates to a process for the preparation of 7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[l,2- b]pyridazin-6-yl)pyrido[l,2-a]pyrimidin-4-one derivatives useful pharmaceutically active compounds.

  本发明涉及一种制备7-(4,7-二氮杂螺[2.5]辛烷-7-基)-2-(2,8-二甲基咪唑并[1,2-b]吡啶并[1,2-a]嘧啶-4-酮衍生物的方法，这些衍生物是有药用活性的化合物。
• Process for the preparation of an indole derivative
  申请人：F. Hoffmann-La Roche AG

  公开号：EP2011783A1

  公开（公告）日：2009-01-07

  A process for the preparation of indole derivatives of formula (I): which are useful as intermediates in the preparation of i.a. pharmaceutically active compounds.

  一种制备式(I)吲哚衍生物的方法：这些衍生物在制备具有药用活性的化合物中起中间体作用。
• METHOD FOR PRODUCING CYANOGEN-HALIDE, CYANATE ESTER COMPOUND AND METHOD FOR PRODUCING THE SAME, AND RESIN COMPOSITION
  申请人：MITSUBISHI GAS CHEMICAL COMPANY, INC.

  公开号：US20150299110A1

  公开（公告）日：2015-10-22

  A method for efficiently producing a cyanogen halide with suppressed side effects, and a method for producing a high-purity cyanate ester compound at a high yield includes contacting a halogen molecule with an aqueous solution containing hydrogen cyanide and/or a metal cyanide, so that the hydrogen cyanide and/or the metal cyanide is allowed to react with the halogen molecule in the reaction solution to obtain the cyanogen halide, wherein more than 1 mole of the hydrogen cyanide or the metal cyanide is used based on 1 mole of the halogen molecule, and when an amount of substance of an unreacted hydrogen cyanide or an unreacted metal cyanide is defined as mole (A) and an amount of substance of the generated cyanogen halide is defined as mole (B), the reaction is terminated in a state in which (A):(A)+(B) is between 0.00009:1 and 0.2:1.

  一种用于高效生产抑制副作用的氰卤化物，以及以高收率生产高纯度氰酸酯化合物的方法包括将卤素分子与含有氢氰酸和/或金属氰化物的水溶液接触，使得氢氰酸和/或金属氰化物与卤素分子在反应溶液中发生反应以获得氰卤化物，其中基于1摩尔卤素分子使用超过1摩尔的氢氰酸或金属氰化物，当未反应的氢氰酸或未反应的金属氰化物的物质量定义为摩尔(A)，生成的氰卤化物的物质量定义为摩尔(B)，反应在(A)：(A)+(B)介于0.00009:1和0.2:1之间的状态中终止。