4-甲基环磷酰胺 | 52663-82-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 4-甲基环磷酰胺
• 英文名称: bis-(2-chloro-ethyl)-(4-methyl-2-oxo-2λ⁵-[1,3,2]oxazaphosphinan-2-yl)-amine
• 英文别名: 4-Methylcyclophosphamide；N,N-bis(2-chloroethyl)-4-methyl-2-oxo-1,3,2λ5-oxazaphosphinan-2-amine
• CAS: 52663-82-8
• 化学式: C₈H₁₇Cl₂N₂O₂P
• 分子量: 275.115
• InChiKey: WVOVAJAOADLLIN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2934999090

文献信息

• MULTI-TARGETED UBENIMEX PRODRUG DERIVATIVE AND PREPARATION METHOD AND USE THEREOF
  申请人：WEIFANG BOCHUANG INTERNATIONAL ACADEMY OF BIOTECHNOLOGY AND MEDICINE

  公开号：US20160193347A1

  公开（公告）日：2016-07-07

  The present invention relates to the design, synthesis, and biological study of multi-targeted Ubenimex pro-drug derivative. More particularly, provided in the present invention is a compound as shown by general structural formula (I) (wherein the definition of R is shown in the description). The derivative is a multi-targeted compound obtained by binding an aminopeptidase (APN/CD13) inhibitor, Ubenimex, with some anti-tumor drugs already on the market through an ester bond or amide bond, and is suitable for use as an anti-tumor drug for the treating various malignant tumors, and is especially suitable for treating various solid tumors.

  本发明涉及多靶向Ubenimex前药衍生物的设计、合成和生物学研究。更具体地，本发明提供了一种化合物，其一般结构式如(I)所示（其中R的定义在描述中给出）。该衍生物是通过酯键或酰胺键将氨肽酶（APN/CD13）抑制剂Ubenimex与市场上已有的一些抗肿瘤药物结合而得到的多靶向化合物，适用于治疗各种恶性肿瘤，特别适用于治疗各种实体肿瘤。