Ritivixibat | 2460667-52-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Ritivixibat
• 英文别名: 3-[(3,3-dibutyl-7-methylsulfanyl-1,1-dioxo-5-phenyl-2,4-dihydro-1λ6,2,5-benzothiadiazepin-8-yl)oxy]propanoic acid
• CAS: 2460667-52-9
• 化学式: C₂₆H₃₆N₂O₅S₂
• 分子量: 520.7
• InChiKey: XHOVXESPVIUTMC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  35
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  130
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Benzothiadiazepine compounds and their use as bile acid modulators
  申请人：Albireo AB

  公开号：US10941127B2

  公开（公告）日：2021-03-09

  The invention relates to 1,2,5-benzothiadiazepine derivatives of formula (I). These compounds are bile acid modulators having apical sodium-dependent bile acid transporter (ASBT) and/or liver bile acid transport (LBAT) inhibitory activity. The invention also relates to pharmaceutical compositions comprising these compounds and to the use of these compounds in the treatment of cardiovascular diseases, fatty acid metabolism and glucose utilization disorders, gastrointestinal diseases and liver diseases.

  本发明涉及式（I）的 1,2,5-苯并噻二氮杂卓衍生物。这些化合物是胆汁酸调节剂，具有顶端钠依赖性胆汁酸转运体（ASBT）和/或肝胆汁酸转运体（LBAT）抑制活性。本发明还涉及包含这些化合物的药物组合物，以及这些化合物在治疗心血管疾病、脂肪酸代谢和葡萄糖利用障碍、胃肠道疾病和肝脏疾病中的用途。
• BENZOTHIADIAZEPINE COMPOUNDS AND THEIR USE AS BILE ACID MODULATORS
  申请人：Albireo AB

  公开号：EP3921028A1

  公开（公告）日：2021-12-15
• [EN] BENZOTHIADIAZEPINE COMPOUNDS AND THEIR USE AS BILE ACID MODULATORS<br/>[FR] COMPOSÉS DE BENZOTHIADIAZÉPINE ET LEUR UTILISATION EN TANT QUE MODULATEURS D'ACIDE BILIAIRE
  申请人：ALBIREO AB

  公开号：WO2020161217A1

  公开（公告）日：2020-08-13

  The invention relates to 1,2,5-benzothiadiazepine derivatives of formula (I). These compounds are bile acid modulators having apical sodium-dependent bile acid transporter (ASBT) and/or liver bile acid transport (LBAT) inhibitory activity. The invention also relates to pharmaceutical compositions comprising these compounds and to the use of these compounds in the treatment of cardiovascular diseases, fatty acid metabolism and glucose utilization disorders, gastrointestinal diseases and liver diseases.